patent blue violet

Modify Date: 2024-01-02 14:25:14

patent blue violet structure	Common Name	patent blue violet
	CAS Number	129-17-9	Molecular Weight	566.665
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₁N₂NaO₆S₂	Melting Point	290ºC
	MSDS	Chinese USA	Flash Point	N/A

Use of patent blue violet

Patent Blue V (Acid blue 1) is a novel biological dye that can be used as an intraocular dye for retinectomy. Retinectomy refers to the removal of the translucent inner limiting membrane (ILM). The application of appropriate dyes in vitreoretinal surgery can achieve the purpose of complete removal. Patent Blue V can be used to stain retinal premembranous structures. Spectral analysis shows that Patent Blue V has strong absorption below 450 nm and above 600 nm, showing a blue-green color. Patent Blue V is also used as a marker in lymphangiography for resection of neoplastic lymph nodes[1][2].

Name	Patent Blue VF
Synonym	More Synonyms

Description	Patent Blue V (Acid blue 1) is a novel biological dye that can be used as an intraocular dye for retinectomy. Retinectomy refers to the removal of the translucent inner limiting membrane (ILM). The application of appropriate dyes in vitreoretinal surgery can achieve the purpose of complete removal. Patent Blue V can be used to stain retinal premembranous structures. Spectral analysis shows that Patent Blue V has strong absorption below 450 nm and above 600 nm, showing a blue-green color. Patent Blue V is also used as a marker in lymphangiography for resection of neoplastic lymph nodes[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Mennel S, et al. Patent blue: a novel vital dye in vitreoretinal surgery. Ophthalmologica. 2006;220(3):190-3. [2]. Barranger E, et al. Laparoscopic sentinel lymph node procedure using a combination of patent blue and radioisotope in women with cervical carcinoma. Cancer. 2003 Jun 15;97(12):3003-9.

Description

Related Catalog

Research Areas >> Cancer

References

[1]. Mennel S, et al. Patent blue: a novel vital dye in vitreoretinal surgery. Ophthalmologica. 2006;220(3):190-3.

[2]. Barranger E, et al. Laparoscopic sentinel lymph node procedure using a combination of patent blue and radioisotope in women with cervical carcinoma. Cancer. 2003 Jun 15;97(12):3003-9.

Melting Point	290ºC
Molecular Formula	C₂₇H₃₁N₂NaO₆S₂
Molecular Weight	566.665
Exact Mass	566.152100
PSA	137.41000
LogP	5.92380
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	1 g/20 mL (20 ºC)

patent blue violet MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP6830000

CHEMICAL NAME :: Ammonium, (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzyli dene)-2,5-cyclohexadi en-1- ylidene)diethyl-, hydroxide, monosodium salt

CAS REGISTRY NUMBER :: 129-17-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C27-H31-N2-O6-S2.Na

MOLECULAR WEIGHT :: 566.71

WISWESSER LINE NOTATION :: L6Y DYJ AUYR DN2&2&R BSWO DSWQ& DUK2&2 &-NA- &35/25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 33 ug/kg

TOXIC EFFECTS :: Immunological Including Allergic - anaphylaxis

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/m3/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3000 mg/kg/33W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2070 mg/kg/50W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4050 mg/kg/45W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 170,75,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,163,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,163,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0027 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 65 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0027 No. of Facilities: 5396 (estimated) No. of Industries: 45 No. of Occupations: 49 No. of Employees: 80939 (estimated) No. of Female Employees: 18204 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T
Risk Phrases	R45
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	BP6830000
HS Code	32041200

HS Code	32041200

[Anaphylaxis to blue dyes].

Rev. Med. Suisse 10(426) , 876-80, (2014)

In medicine, vital blue dyes are mainly used for the evaluation of sentinel lymph nodes in oncologic surgery. Perioperative anaphylaxis to blue dyes is a rare but significant complication. Allergic re...

Evaluation of potential genotoxicity of five food dyes using the somatic mutation and recombination test.

Chemosphere 88(8) , 974-9, (2012)

In this study, different concentrations of five food dyes (amaranth, patent blue, carminic acid, indigotine and erythrosine) have been evaluated for genotoxicity in the Somatic Mutation and Recombinat...

[Determination of sixteen food additives in beverage by capillary zone electrophoresis].

Se Pu 30(7) , 747-51, (2012)

A capillary zone electrophoretic (CZE) method for the separation of ten synthetic colorants such as acid red 92, patent blue V, uranine, acid red 1, indigo carmine, black BN, ponceau 6R, quinoline, am...

sodium,4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,3-disulfonate

Sodium 4-{[4-(diethylamino)phenyl][4-(diethyliminio)cyclohexa-2,5-dien-1-ylidene]methyl}benzene-1,3-disulfonate

Patent Blue VF,indicator grade

EINECS 204-934-1

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Natrium-4-{[4-(diethylamino)phenyl][4-(diethyliminio)cyclohexa-2,5-dien-1-yliden]methyl}benzol-1,3-disulfonat

MFCD00012119

Ethanaminium, N-[4-[[4-(diethylamino)phenyl](2,4-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, inner salt, sodium salt (1:1)

patent blue violet

4-{[4-(diéthylamino)phényl][4-(diéthyliminio)cyclohexa-2,5-dién-1-ylidène]méthyl}benzène-1,3-disulfonate de sodium

Sodium 4-{[4-(diethylamino)phenyl][4-(diethyliminio)-2,5-cyclohexadien-1-ylidene]methyl}-1,3-benzenedisulfonate

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: patent blue violet
Price: ￥178.0/5g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Acid blue 1
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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