MRT-81
Modify Date: 2024-01-09 17:36:35
MRT-81 structure
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Common Name | MRT-81 | ||
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| CAS Number | 1263132-08-6 | Molecular Weight | 555.64 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H29N3O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRT-81MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1]. |
| Name | MRT-81 |
|---|
| Description | MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
IC50: 41 nM (Shh-light2 cells Smo receptors)[1] |
| In Vitro | MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC50 value of 64 nM[1]. MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC50 less than 10 nM[1]. MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM, 2 h, 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC50 of 63 nM in HEK-hSmo cells[1]. |
| References |
| Molecular Formula | C31H29N3O5S |
|---|---|
| Molecular Weight | 555.64 |