MG149
Modify Date: 2024-01-02 07:32:00
MG149 structure
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Common Name | MG149 | ||
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| CAS Number | 1243583-85-8 | Molecular Weight | 340.45600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H28O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MG149MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM); little potent for PCAF and p300(IC50 >200 uM).IC50 value: 74/47 uM (Tip60/MOF) [1]Target: Tip60/MOFMG 149, at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentiallycompetitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extractsof different regions significantly (p < 0.05). |
| Name | 2-(4-heptylphenethyl)-6-hydroxybenzoic acid |
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| Synonym | More Synonyms |
| Description | MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM); little potent for PCAF and p300(IC50 >200 uM).IC50 value: 74/47 uM (Tip60/MOF) [1]Target: Tip60/MOFMG 149, at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentiallycompetitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extractsof different regions significantly (p < 0.05). |
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| Related Catalog | |
| References |
| Molecular Formula | C22H28O3 |
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| Molecular Weight | 340.45600 |
| Exact Mass | 340.20400 |
| PSA | 57.53000 |
| LogP | 5.38850 |
| Storage condition | -20℃ |
| MG149 |
| MG 149 |