Azelaic acid

Modify Date: 2024-01-02 15:21:22

Azelaic acid structure	Common Name	Azelaic acid
	CAS Number	123-99-9	Molecular Weight	188.221
	Density	1.1±0.1 g/cm3	Boiling Point	286 ºC (100 mmHg)
	Molecular Formula	C₉H₁₆O₄	Melting Point	98-103 ºC
	MSDS	Chinese USA	Flash Point	215 ºC
	Symbol	GHS07	Signal Word	Warning

Use of Azelaic acid

Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.

Name	azelaic acid
Synonym	More Synonyms

Description	Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324(5923):89-91. [2]. Liu RH, et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006 Aug;142(8):1047-52.

Density	1.1±0.1 g/cm3
Boiling Point	286 ºC (100 mmHg)
Melting Point	98-103 ºC
Molecular Formula	C₉H₁₆O₄
Molecular Weight	188.221
Flash Point	215 ºC
Exact Mass	188.104858
PSA	74.60000
LogP	1.33
Vapour density	6.5 (vs air)
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.475
Stability	Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.
Water Solubility	2.4 g/L (20 ºC)

Azelaic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM1980000

CHEMICAL NAME :: Azelaic acid

CAS REGISTRY NUMBER :: 123-99-9

BEILSTEIN REFERENCE NO. :: 1101094

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H16-O4

MOLECULAR WEIGHT :: 188.25

WISWESSER LINE NOTATION :: QV7VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A067-313 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83495 No. of Facilities: 170 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 1676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83495 No. of Facilities: 3427 (estimated) No. of Industries: 35 No. of Occupations: 42 No. of Employees: 34469 (estimated) No. of Female Employees: 7576 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	CM1980000
HS Code	2917139000

Precursor 10
CAS#:112-80-1 oleic acid CAS#:112-62-9 Methyl oleate CAS#:137-21-3 Octadecanedioic... CAS#:24753-49-9 ω-carboxyl OA d...
CAS#:120-87-6 9,10-dihydroxys... CAS#:37056-34-1 8-cyanooctanoic acid CAS#:14436-32-9 9-Decenoic acid CAS#:141-22-0 ricinoleic acid
CAS#:373-49-9 Palmitoleic acid CAS#:112-79-8 Elaidic Acid
DownStream 10
CAS#:105-03-3 bis(2-ethylbuty... CAS#:106664-96-4 Nonanedioic aci... CAS#:3788-56-5 9-HYDROXYNONANO... CAS#:4080-95-9 Nonanedioic aci...
CAS#:593-49-7 Heptacosane CAS#:4549-33-1 1,9-Dibromononane CAS#:4549-31-9 1,7-Dibromoheptane CAS#:34957-73-8 8-Methoxycarbon...
CAS#:3937-56-2 1,9-Nonanediol CAS#:502-49-8 Cyclooctanone

HS Code	2917139000
Summary	2917139000 azelaic acid, sebacic acid, their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Azelaic acid
Price: ￥108.0/100g ￥418.0/500g
Purity: 99.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Azelaic acid
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Azelaic acid suppliers in China
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Azelaic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinDMSO

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