Tyrphostin 47

Modify Date: 2024-01-05 13:31:08

Tyrphostin 47 structure	Common Name	Tyrphostin 47
	CAS Number	122520-86-9	Molecular Weight	220.248
	Density	1.5±0.1 g/cm3	Boiling Point	474.5±55.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	240.8±31.5 °C

Use of Tyrphostin 47

Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].

Name	3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
Synonym	More Synonyms

Description	Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	Tyrphostin AG213 (25 μM, 50 μM, 和 75 μM; 24 h, 48 h, 和 96 h) 增加人脐静脉内皮细胞 (HUVEC) 单层的伤口闭合时间[1]。 Tyrphostin AG213 (100 μM; 1 h) 干扰 HUVEC 焦点粘附和应力纤维形成[1]。 Tyrphostin AG213 (100 μM; 24 h) 抑制 HUVEC 中 pp125FAK 的粘附相关酪氨酸磷酸化[1]。 Tyrphostin AG213 (10 μM; 24 h) 抑制酪氨酸激酶活性，并且呈剂量和时间依赖关系地抑制 HT-29 细胞活力[2]。
References	[1]. Romer LH, et al. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell. 1994 Mar;5(3):349-61.

Density	1.5±0.1 g/cm3
Boiling Point	474.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₀H₈N₂O₂S
Molecular Weight	220.248
Flash Point	240.8±31.5 °C
Exact Mass	220.030655
PSA	122.36000
LogP	0.93
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.780
Storage condition	2-8°C
Water Solubility	DMSO: 50 mg/mL, clear, orange

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
WGK Germany	3

2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-

Tyrphostin 47

IN1038

(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenethioamide

(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide

Tyrphostin 47

Use of Tyrphostin 47

Names

Tyrphostin 47 Biological Activity

Chemical & Physical Properties

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