Skepinone-L

Modify Date: 2024-01-03 13:26:07

Skepinone-L structure	Common Name	Skepinone-L
	CAS Number	1221485-83-1	Molecular Weight	425.425
	Density	1.4±0.1 g/cm3	Boiling Point	629.0±55.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₁F₂NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	334.2±31.5 °C

Use of Skepinone-L

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. IC50 value:Target: p38MAPKskepinone-L, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors.

Name	3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
Synonym	More Synonyms

Description	Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. IC50 value:Target: p38MAPKskepinone-L, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
References	[1]. Koeberle, Solveigh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nature Chemical Biology (2012), 8(2), 141-143. [2]. Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal Chemistry (2012), 55(12), 5868-5877.

Description

Related Catalog

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

References

[1]. Koeberle, Solveigh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nature Chemical Biology (2012), 8(2), 141-143.

[2]. Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal Chemistry (2012), 55(12), 5868-5877.

Density	1.4±0.1 g/cm3
Boiling Point	629.0±55.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₁F₂NO₄
Molecular Weight	425.425
Flash Point	334.2±31.5 °C
Exact Mass	425.143860
PSA	78.79000
LogP	4.95
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.646
Storage condition	-20℃

N/A

CAS#:1353948-60-3

~97%

Skepinone-L

CAS#:1221485-83-1

Literature: Laufer, Stefan; Albrecht, Wolfgang Patent: US2012/115862 A1, 2012 ; Location in patent: Page/Page column 21 ;

Skepinone-L

Skepinone-L|

3que

5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-

CS-0941

2-(2,4-difluorophenylamino)-7-[2R,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]cyclohepten-5-one

X5940

S7214

2-(2,4-Difluorophenylamino)-7-[2R-,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one

2-(2,4-difluoroanilino)-7-[2-(R)-3-dihydroxypropoxy]-10,11-dihydrodibenzo[a,d]cyclohepten-5-one

DC Chemicals Limited
China
Product Name: Skepinone-L
Price: $600.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Skepinone-L suppliers

Price: $377/10mM*1mLinDMSO

Reference only. check more Skepinone-L price

Skepinone-L

Use of Skepinone-L

Names

Skepinone-L Biological Activity

Chemical & Physical Properties

Synthetic Route

Synonyms