LUF5771

Modify Date: 2024-01-10 11:30:21

LUF5771 Structure
LUF5771 structure
Common Name LUF5771
CAS Number 1141802-49-4 Molecular Weight 357.44
Density N/A Boiling Point N/A
Molecular Formula C24H23NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LUF5771


LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy[1].

 Names

Name LUF5771

 LUF5771 Biological Activity

Description LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy[1].
Related Catalog
Target

recLH and Org 43553[1]

In Vitro LUF5771 (1 µM or 10 µM) allosteric inhibition is concentration-dependent. LUF5771 significantly increases radioligand dissociation. LUF5771 probably binds to the seven transmembrane domain like Org 43553 does. LUF5771 (10 µM) alone is able to partially activate the LH receptor by 31±4%[1].
References

[1]. Laura H. Heitman, et al. Substituted Terphenyl Compounds as the First Class of Low Molecular Weight Allosteric Inhibitors of the Luteinizing Hormone Receptor. Journal of Medicinal Chemistry 2009 52 (7), 2036-2042

 Chemical & Physical Properties

Molecular Formula C24H23NO2
Molecular Weight 357.44
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