Olprinone

Modify Date: 2024-01-03 11:44:22

Olprinone Structure
Olprinone structure
 Common Name Olprinone
CAS Number 106730-54-5 Molecular Weight 250.255
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C14H10N4O Melting Point >300ºC
MSDS N/A Flash Point N/A

 Use of Olprinone


Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury.

 Names

Name 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile
Synonym More Synonyms

 Olprinone Biological Activity

Description Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury.
Related Catalog
References

[1]. Tsubokawa T, Ishizuka S, Fukumoto K, et al. The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone. J Anesth. 2012 .

[2]. Mokra D, Drgova A, Pullmann R Sr, et al. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22.

[3]. Yamanaka H, Hayashi Y, Kamibayashi T, Mashimo T. Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass. J Cardiovasc Pharmacol. 2011 May;57(5):579-83.

[4]. Mazzon E, Esposito E, Di Paola R, et al. Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. Pharmacol Res. 2011 Jul;64(1):68-79.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Melting Point >300ºC
Molecular Formula C14H10N4O
Molecular Weight 250.255
Exact Mass 250.085464
PSA 73.95000
LogP 1.03
Index of Refraction 1.703

 Safety Information

Hazard Codes T,N,C
Risk Phrases R25:Toxic if swallowed. R34:Causes burns. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R24/25:Toxic in contact with skin and if swallowed . R36:Irritating to the eyes.
Safety Phrases S26-S36-S45-S61-S36/37/39
RIDADR UN 2922 8/PG 2
WGK Germany 3
RTECS AK5110000
Packaging Group II
Hazard Class 8
HS Code 29183000

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxonicotinonitrile
Olprinone [INN]
1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile
5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
UNII-4Y8BMI9YGC
Loprinone
Coretec
3-Pyridinecarbonitrile, 1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
MFCD00868774
Olprinone
1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
Olprinone|
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Related Compounds: More...
Olprinone Impurity 2
106730-62-5
Olprinone Impurity A
141354-29-2
Olprinone hydrochloride
119615-63-3
Chemsrc provides Olprinone(CAS#:106730-54-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Olprinone are included as well.>> amp version: Olprinone

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