Phenanthridin-6(5H)-one

Modify Date: 2024-01-02 16:37:51

Phenanthridin-6(5H)-one structure	Common Name	Phenanthridin-6(5H)-one
	CAS Number	1015-89-0	Molecular Weight	195.22
	Density	1.2±0.1 g/cm3	Boiling Point	274.8±7.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₉NO	Melting Point	290-292 °C(lit.)
	MSDS	USA	Flash Point	158.7±3.1 °C

Use of Phenanthridin-6(5H)-one

6(5H)-Phenanthridinone is a potent PARP-1 inhibitor and immunomodulator. 6(5H)-Phenanthridinone inhibits cell proliferation and can be used in cancer research[1].

Name	phenanthridone
Synonym	More Synonyms

Description	6(5H)-Phenanthridinone is a potent PARP-1 inhibitor and immunomodulator. 6(5H)-Phenanthridinone inhibits cell proliferation and can be used in cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Weltin D, et al. Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor. Int J Immunopharmacol. 1995 Apr;17(4):265-71.

Density	1.2±0.1 g/cm3
Boiling Point	274.8±7.0 °C at 760 mmHg
Melting Point	290-292 °C(lit.)
Molecular Formula	C₁₃H₉NO
Molecular Weight	195.22
Flash Point	158.7±3.1 °C
Exact Mass	195.068420
PSA	32.86000
LogP	2.81
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.642
Storage condition	2-8°C

Phenanthridin-6(5H)-one MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG0370000

CHEMICAL NAME :: 6(5H)-Phenantridinone

CAS REGISTRY NUMBER :: 1015-89-0

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H9-N-O

MOLECULAR WEIGHT :: 195.23

WISWESSER LINE NOTATION :: T B666 HMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: LMF-84

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SG0370000
HS Code	2933990090

Precursor 10
CAS#:201230-82-2 carbon monoxide CAS#:90-41-5 2-Aminodiphenyl CAS#:10282-57-2 2-bromo-N-pheny... CAS#:13234-79-2 [1,1'-Biphenyl]...
CAS#:54147-90-9 2-(2-iodophenyl... CAS#:486-25-9 9-Fluorenone CAS#:24310-30-3 N-(2-Biphenylyl... CAS#:2157-52-0 9-fluorenone oxime
CAS#:609-73-4 1-Iodo-2-nitrob... CAS#:610-97-9 Methyl 2-iodobe...
DownStream 10
CAS#:229-87-8 Phenanthridine CAS#:27353-48-6 2-Bromophenanth... CAS#:25491-54-7 5-Ethylphenanth... CAS#:27353-44-2 6(5H)-Phenanthr...
CAS#:17613-40-0 6-Bromophenanth... CAS#:15679-03-5 6-Chlorophenant... CAS#:37045-19-5 ethyl 2-(6-oxop... CAS#:23441-13-6 6-(4-methylpipe...
CAS#:137531-20-5 2-nitrophenanth... CAS#:27799-79-7 5,6-dihydrophen...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors.

Bioorg. Med. Chem. Lett. 19 , 2444-7, (2009)

Benz[b]oxepines 4a-g and 12-oxobenzo[c]phenanthridines 5a-d were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular radical cyclization reaction. Radical cy...

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.

J. Pharmacol. Exp. Ther. 305(3) , 943-9, (2003)

Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy failure by NAD and A...

Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy.

Org. Lett. 10(3) , 361-4, (2008)

Solid-state silica-gel-catalyzed opening of aziridine 6 provided phenanthrene 7, whose oxidative cleavage, recyclization, and further elaboration furnished the C-1 aldehyde and carboxylic acid derivat...

phenanthridone

6-phenanthridinol

phenanthridin-6(5H)-one

EINECS 213-804-3

phenanthridin-6-ol

6-(5H)-Phenanthridinone

MFCD00004988

6-Hydroxyphenanthridine

5,6-dihydrophenanthridin-6-one

6(5H)-Phenanthridinone

6(5H)-Phenanthridone

5H-phenanthridin-6-one

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phenanthridin-6(5H)-one
Price: ￥248.0/1g ￥958.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 6(5H)-Phenanthridinone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6(5H)Phenanthridinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥105/1 g

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