Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Bafilomycin B1
Price: ￥2138.0/1mg
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

88899-56-3

88899-56-3 structure

88899-56-3 structure

Name: Bafilomycin B1
Chemical Name: Bafilomycin B1
CAS Number: 88899-56-3
Molecular Formula: C₄₄H₆₅NO₁₃
Molecular Weight: 815.986
Catalog: API Synthetic anti-infective drugs Antifungal drugs
Create Date: 2018-06-22 11:27:07
Modify Date: 2024-01-06 11:56:47
Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli[1].

Name	Bafilomycin B1
Synonyms	(5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO-MYCES SPECIES bafilomycin b1from streptomyces sp. α-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-3 -O-[(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-buten-1-yl]-4-methyl-5-C-(1-methylethyl)-, (5R)- ino)carbonyl)-2-methoxy-24-methyl BafilomycinB1fromStreptomycesgriseus MFCD00214150

Description	Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Bowman EJ, et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7972-6.

Density	1.2±0.1 g/cm3
Boiling Point	939.4±65.0 °C at 760 mmHg
Molecular Formula	C₄₄H₆₅NO₁₃
Molecular Weight	815.986
Flash Point	521.9±34.3 °C
Exact Mass	815.445618
PSA	207.38000
LogP	3.06
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.563
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NG8841000

CHEMICAL NAME :: Hygrolidin, 37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclo penten-1-yl)amino)car bonyl)- 2-methoxy-24-methyl-

CAS REGISTRY NUMBER :: 88899-56-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C44-H65-N-O13

MOLECULAR WEIGHT :: 816.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1253,1981

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H310 + H330
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R26/27/28
Safety Phrases	36/37/39-45
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	NG8841000

Precursor 0
DownStream 1
65518-38-9