138-92-1

138-92-1 structure

Name: Betazole dihydrochloride
Chemical Name: betazole dihydrochloride
CAS Number: 138-92-1
Molecular Formula: C₅H₁₁Cl₂N₃
Molecular Weight: 184.06700
Catalog: API Diagnostic medication Organ function test agent
Create Date: 2018-04-13 08:00:00
Modify Date: 2024-01-06 19:25:22
Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].

Name	betazole dihydrochloride
Synonyms	1h-pyrazole-3-ethanamine,dihydrochloride BETAZOLE HYDROCHLORIDE (200 MG) 3-(2-aminoethyl)-pyrazoldihydrochloride histalog [2-(1H-Pyrazol-3-yl)ethyl]amine dihydrochloride ametazoledihydrochloride Betazole hydrochloride 2-(1(2)H-pyrazol-3-yl)-ethylamine,dihydrochloride gastramine 2-(1(2)H-Pyrazol-3-yl)-aethylamin,Dihydrochlorid 3-(2-aminoethyl)pyrazole,dihydrochloride Histimin

Description	Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H2 Receptor
In Vitro	Betazole (Ametazole) dihydrochloride is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole dihydrochloride induces gastric inhibitory polypeptide (GIP) secretion[1].
References	[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human)

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,275,1986

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,274,1986

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 122,685,1966

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,749,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83995 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated)

Hazard Codes	Xn
RIDADR	NONH for all modes of transport
HS Code	2933199090

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%