5985-28-4

5985-28-4 structure

Name: Synephrine hydrochloride
Chemical Name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol,hydrochloride
CAS Number: 5985-28-4
Molecular Formula: C₉H₁₄ClNO₂
Molecular Weight: 203.666
Catalog: Biochemical Inhibitor Neuronal Signaling Adrenergic Receptor Agonist
Create Date: 2018-04-23 08:00:00
Modify Date: 2024-01-04 11:03:13
Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine.

Name	4-[1-hydroxy-2-(methylamino)ethyl]phenol,hydrochloride
Synonyms	UNII:EN5D1IH09S DL-synephrine hydrochloride EINECS 227-804-6 Synephrine HCl 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride MFCD00050566 Synephrine hydrochloride 4-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1) 2-methylamino-1-(4-hydroxyphenyl)-ethanol hydrochloride Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, hydrochloride (1:1) (+-)-1-(4-hydroxy-phenyl)-2-methylamino-ethanol,hydrochloride Oxedrine hydrochloride Ocuton (TN) 1-(4-Hydroxy-phenyl)-2-methylamino-aethanol,Hydrochlorid

Description	Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Synephrine, From Wikipedia

CHEMICAL NAME :: Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-, hydrochloride

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927

Hazard Codes	Xi
HS Code	2922199090

Precursor 0
DownStream 1
14593-25-0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%