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104-29-0

104-29-0 structure
104-29-0 structure
  • Name: Chlorphenesin
  • Chemical Name: chlorphenesin
  • CAS Number: 104-29-0
  • Molecular Formula: C9H11ClO3
  • Molecular Weight: 202.635
  • Catalog: API Synthetic anti-infective drugs Antifungal drugs
  • Create Date: 2018-07-13 00:30:11
  • Modify Date: 2024-01-04 15:20:59
  • Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics[1].

Name chlorphenesin
Synonyms Gecophen
Adermykon
Demykon
EINECS 203-192-6
3-(4-Chlorophenoxy)-1,2-propanediol
3-(4-chlorophenoxy)propane-1,2-diol
Chlorphenesinum
3-(p-Chlorophenoxy)propane-1,2-diol
Mycil
1,2-Propanediol, 3- (p-chlorophenoxy)-
p-chlorophenyl a-glyceryl ether
Chlorphenesine
Clorfenesina
MFCD00021990
Chlorphenesin
1,2-Propanediol, 3-(4-chlorophenoxy)-
Chlorophenesin
Description Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics[1].
Related Catalog
In Vitro Chlorphenesin (0.01, 0.1, 0.3%; 30-min exposure) significantly reduces the activity of the Akt pathway in a dose-dependent manner in human meibomian gland epithelial cells (HMGECs)[2]. Chlorphenesin (0.1, 0.3%; 24 hours) induces immortalized HMGECs (IHMGECs) rounding, atrophy, poor adherence, detachme and significantly reduces the number of IHMGECs[2].
References

[1]. H Y Whang, et al. Chlorphenesin: an antigen-associated immunosuppressant. Infect Immun. 1970 Jul;2(1):60-4.

[2]. Jingyi Wang, et al. Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells. Exp Eye Res. 2020 Jul;196:108057.

Density 1.3±0.1 g/cm3
Boiling Point 369.5±27.0 °C at 760 mmHg
Melting Point 77-79°C
Molecular Formula C9H11ClO3
Molecular Weight 202.635
Flash Point 177.2±23.7 °C
Exact Mass 202.039673
PSA 49.69000
LogP 1.43
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.565
Material Safety Data Sheet

Section1. Identification of the substance
Chlorphenesin
Product Name:
Synonyms:3-(4-Chlorophenoxy)-1,2-Propanediol

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340:IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405:Store locked up

Section3. Composition/information on ingredients.
Chlorphenesin
Ingredient name:
CAS number:104-29-0

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C9H11ClO3
Molecular weight:202.6

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TY4260000
CHEMICAL NAME :
1,2-Propanediol, 3-(p-chlorophenoxy)-
CAS REGISTRY NUMBER :
104-29-0
BEILSTEIN REFERENCE NO. :
2210845
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H11-Cl-O3
MOLECULAR WEIGHT :
202.65
WISWESSER LINE NOTATION :
Q1YQ1OR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
911 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,470,1948
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S26-S36
HS Code 2909499000
HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%