87-41-2

87-41-2 structure

Name: Phthalide
Chemical Name: 2-benzofuran-1(3H)-one
CAS Number: 87-41-2
Molecular Formula: C₈H₆O₂
Molecular Weight: 134.132
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-08-11 17:26:48
Modify Date: 2024-01-02 15:27:48
Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant[1][2][3].

Name	2-benzofuran-1(3H)-one
Synonyms	1-Isobenzofuranone Rabcide EINECS 201-744-0 1(3H)-4,5,6,7-tetrachloroisobenzofuranone Fthalide 3-oxo-1,3-dihydro-isobenzofuran MFCD00005906 5-17-10-00007 (Beilstein Handbook Reference) 1(3H)-Isobenzofuranone isobenzofuran-1-one 1-Phthalanone KF-32 2-Hydroxymethylbenzoic acid, γ-lactone PHH 4,5,6,7-tetrachloro-1(3H)-isobenzofuranone 4,5,6,7-Tetrachlorophthalidefthalide 4,5,6,7-Tetrachlor-phthalid Phthalide 2-Benzofuran-1(3H)-one 1H-Isobenzofuran-3-one T56 BVO DHJ 4,5,6,7-TETRACHLOROPHTHALIDE 4,5,6,7-tetrachloroisobenzofuran-1(3H)-one Isobenzofuranone Phthalolactone

Description	Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Liu Zeng Chen, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020 Nov 15;206:112722. [2]. Chakapong Intaraudom, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [3]. Xin Fang, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. J Asian Nat Prod Res. 2020 Dec;22(12):1176-1187.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,25,1953

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TI3520000
HS Code	29322980