Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phenolphthalein
Price: ￥88.0/100g ￥288.0/500g ￥48.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Phenolphthalein
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phenolphthalein
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Phenolphthalein
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

77-09-8

77-09-8 structure

Name: Phenolphthalein
Chemical Name: Phenolphthalein
CAS Number: 77-09-8
Molecular Formula: C₂₀H₁₄O₄
Molecular Weight: 318.323
Catalog: API Digestive system medication Laxative antidiarrheal
Create Date: 2018-02-03 08:00:00
Modify Date: 2024-01-02 17:27:43
Phenolphthalein is a widely applied but toxic indicator dye.

Name	Phenolphthalein
Synonyms	Evac-U-Gen a-(p-Hydroxyphenyl)-a-(4-oxo-2,5-cyclohexadien-1-ylidine)-o-toluic Acid Phenolphthalein White phenolphthalein Evac-Q-Kit Ex-Lax Evac-Q-Tabs MFCD00005913 Chocolax EINECS 201-004-7 Evac-Q-Kwik 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofurunone 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)- 5-18-04-00188 (Beilstein Handbook Reference) Colax Purgophen (VAN) Feen-A-Mint Laxative Mints 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one 3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one Evac-V-Lax

Description	Phenolphthalein is a widely applied but toxic indicator dye.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Dye Reagents
References	[1]. Fleischmann C, et al. Color indicator for supramolecular polymer chemistry: phenolphthalein-containing thermo- and pH-sensitive N-(Isopropyl)acrylamide copolymers and β-cyclodextrin complexation. Macromol Rapid Commun. 2013 Jul 12;34(13):1085-9.

Density	1.4±0.1 g/cm3
Boiling Point	557.8±50.0 °C at 760 mmHg
Melting Point	258-263 °C
Molecular Formula	C₂₀H₁₄O₄
Molecular Weight	318.323
Flash Point	206.5±23.6 °C
Exact Mass	318.089203
PSA	66.76000
LogP	2.63
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.693
Stability	Stable. Incompatible with strong oxidizing agents, alkalies.
Water Solubility	<0.1 g/100 mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM8380000

CHEMICAL NAME :: Phenolphthalein

CAS REGISTRY NUMBER :: 77-09-8

BEILSTEIN REFERENCE NO. :: 0284423

LAST UPDATED :: 199803

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C20-H14-O4

MOLECULAR WEIGHT :: 318.34

WISWESSER LINE NOTATION :: T56 BVO DHJ D- D-/R DQ 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Gastrointestinal - gastritis Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 324 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 106 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 364 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 281 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,151,1995 *** REVIEWS *** TOXICOLOGY REVIEW DAPOAG Deutsche Apotheker. (Postfach 1650, 6370 Oberusel/Taunas, Fed. Rep. Ger.) V.1- 1949- Volume(issue)/page/year: 27,151,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0011 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 31 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 56240 No. of Facilities: 6160 (estimated) No. of Industries: 102 No. of Occupations: 43 No. of Employees: 43092 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9187 No. of Facilities: 117 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1946 (estimated) No. of Female Employees: 1408 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 56240 No. of Facilities: 6900 (estimated) No. of Industries: 89 No. of Occupations: 57 No. of Employees: 73297 (estimated) No. of Female Employees: 18309 (estimated)

Symbol	GHS02, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H225-H319-H341-H350
Precautionary Statements	P201-P210-P280-P308 + P313-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R40
Safety Phrases	S45-S36/37-S33-S24-S16-S7
RIDADR	UN 1993
RTECS	SM8380000
Hazard Class	3.0
HS Code	29322910

85-44-9

108-95-2

~96%

77-09-8

Literature: Sabnis, Ram W. Tetrahedron Letters, 2009 , vol. 50, # 46 p. 6261 - 6263

85-57-4

108-95-2

77-09-8

Literature: Ghatak Bl. Acad. Sci. Agra Oudh, 1933 , vol. 2, p. 253,255

85-44-9

108-95-2

77-09-8

596-24-7

Literature: Baeyer Justus Liebigs Annalen der Chemie, 1882 , vol. 212, p. 349 Full Text Show Details Meyer,R. Chemische Berichte, 1891 , vol. 24, p. 1414,2600 Chemische Berichte, 1893 , vol. 26, p. 205 Full Text Show Details Baeyer Chemische Berichte, 1871 , vol. 4, p. 659 Chemische Berichte, 1876 , vol. 9, p. 1233 Full Text Show Details Baeyer Justus Liebigs Annalen der Chemie, 1880 , vol. 202, p. 56,63

62625-15-4

77-09-8

Literature: Nishizawa, Masako; Yabusaki, Yoshiyasu; Kanaoka, Masaharu Bioscience, Biotechnology and Biochemistry, 2011 , vol. 75, # 1 p. 89 - 94

88-99-3

108-95-2

77-09-8

Literature: Copisarow Journal of the Chemical Society, 1920 , vol. 117, p. 215

509-77-3

77-09-8

Literature: Baeyer Chemische Berichte, 1879 , vol. 12, p. 644 Justus Liebigs Annalen der Chemie, 1880 , vol. 202, p. 52

84755-69-1

77-09-8

Literature: Yamaguchi; Mori; Suketa Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 159 - 163

Precursor 7
85-44-9 108-95-2 85-57-4 62625-15-4
88-99-3 509-77-3 84755-69-1
DownStream 10
462-47-5 2012-29-5 609-23-4 108-95-2
21147-23-9 123-31-9 88-99-3 605-32-3
129-43-1 85-57-4

HS Code	29322910

77-09-8	5768-87-6
2037-19-6	25296-54-2
6607-41-6	52404-53-2
6607-42-7	8053-05-2
29717-26-8	62698-58-2