89796-99-6

89796-99-6 structure

Name: Aceclofenac
Chemical Name: aceclofenac
CAS Number: 89796-99-6
Molecular Formula: C₁₆H₁₃Cl₂NO₄
Molecular Weight: 354.185
Catalog: API Antipyretic analgesics Non-steroidal anti-inflammatory drugs
Create Date: 2018-06-10 17:13:09
Modify Date: 2024-01-02 19:21:58
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.Target: COXAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac [1].

Name	aceclofenac
Synonyms	Acelofenac Aceclofenac EINECS 205-783-4 Aceclofar Preservex MFCD00864296 Falcol (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}acetoxy)acetic acid Tresquim Biofenac Zerodol Airtal PR-82/3 Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester Gerbin

Description	Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.Target: COXAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac [1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-2:3 μM (IC50) COX-1:7.3 μM (IC50)
References	[1]. Dannhardt G, et al. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Inflamm Res. 2001 May;50(5):262-9.

CHEMICAL NAME :: Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, carboxymethyl ester

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1265,1991

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H319-H410
Precautionary Statements	P273-P301 + P310-P305 + P351 + P338-P501
Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
RIDADR	2811.0
WGK Germany	3
Hazard Class	6.1
HS Code	2922509090

139272-68-7

~56%

89796-99-6

Literature: US2004/24057 A1, ; Page/Page column 53 ;

15307-79-6

89796-99-6

Literature: Journal of Crystallographic and Spectroscopic Research, , vol. 22, # 3 p. 323 - 328

100499-89-6

89796-99-6

Literature: Journal of Crystallographic and Spectroscopic Research, , vol. 22, # 3 p. 323 - 328

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%