138-60-3

138-60-3 structure

Name: chelidamic acid
Chemical Name: Chelidamic acid
CAS Number: 138-60-3
Molecular Formula: C₇H₅NO₅
Molecular Weight: 183.118
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Dihydropyridine
Create Date: 2019-01-08 19:09:56
Modify Date: 2024-01-02 13:42:13
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.

Name	Chelidamic acid
Synonyms	Pd(OH)2/C chelidamic acid 4-Hydroxypyridine-2,6-dicarboxylic Acid Monohydrate 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid MFCD00066478 4-Hydroxy-2,6-pyridinedicarboxylic acid 4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid 4-PYRIDONE-2,6-DICARBOXYLIC ACID 1,4-dihydro-4-oxo-2,6-pyridinedicarboxylic acid .HELIDAMIC AICD 2,6-Pyridinedicarboxylic acid, 1,4-dihydro-4-oxo- CHELIDAMIC ACID HYDRATE Chelidamaic acid Chelidamic Acid Monohydrate Chelidamic aicd 2,6-Pyridinedicarboxylic acid, 4-hydroxy- Ammox-chelidonic acid 4-Hydroxypyridine-2,6-dicarboxylic acid chelidamic acid approx. EINECS 205-335-8 4-hydroxyl-pyridine-2,6-dicarboxylic acid

Description	Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
Target	Ki: 33 μM (Glutamate decarboxylase)[3].
In Vitro	Chelidamic acid is a heterocyclic organic acid with a pyran skeleton[1]. Chelidamic acid has good coordination ability with noble metal ions[2]. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM[3].
References	[1]. Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55. [2]. Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39(16):3645-51. [3]. Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50.

Density	1.7±0.1 g/cm3
Boiling Point	428.3±45.0 °C at 760 mmHg
Melting Point	267 °C (dec.)(lit.)
Molecular Formula	C₇H₅NO₅
Molecular Weight	183.118
Flash Point	212.8±28.7 °C
Exact Mass	183.016769
PSA	107.46000
LogP	-1.43
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.635

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933399090

99-32-1

~92%

138-60-3

Literature: Horvath, Gyoergy; Rusa, Cristian; Koentoes, Zoltan; Gerencser, Janos; Huszthy, Peter Synthetic Communications, 1999 , vol. 29, # 21 p. 3719 - 3731

Precursor 1
99-32-1
DownStream 10
109880-40-2 53389-01-8 4722-94-5 5371-70-0
184870-12-0 1817-20-5 18986-54-4 19872-91-4
206647-42-9 126769-30-0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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