Name | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol |
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Synonyms |
β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl
Gastrodin Hemihydrate MFCD00272169 4-(hydroxymethyl)phenyl |A-d-glucopyranoside Gastrodin Gastrodin,Gastrodine S2383_Selleck 4-(Hydroxymethyl)phenyl β-D-glucopyranoside Gastrodine |
Description | Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia. |
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Related Catalog | |
In Vitro | Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1]. |
In Vivo | Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1]. |
Cell Assay | Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1]. |
Animal Admin | Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1]. |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 563.2±50.0 °C at 760 mmHg |
Melting Point | 154-157ºC |
Molecular Formula | C13H18O7 |
Molecular Weight | 286.278 |
Flash Point | 294.4±30.1 °C |
Exact Mass | 286.105255 |
PSA | 119.61000 |
LogP | -1.85 |
Vapour Pressure | 0.0±1.6 mmHg at 25°C |
Index of Refraction | 1.638 |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Precautionary Statements | P301 + P312 + P330 |
Hazard Codes | Xi |
Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | LZ5776885 |
Precursor 9 | |
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DownStream 0 |