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  • Product Name: Ormetoprim
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Related CAS#:
6981-18-6 8076-37-7

6981-18-6

6981-18-6 structure
6981-18-6 structure
  • Name: Ormetoprim
  • Chemical Name: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine
  • CAS Number: 6981-18-6
  • Molecular Formula: C14H18N4O2
  • Molecular Weight: 274.318
  • Catalog: API Antibiotics Other antibiotics
  • Create Date: 2018-03-07 08:00:00
  • Modify Date: 2024-01-07 12:28:12
  • Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2].
Name 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine
Synonyms UNII-M3EFS94984
5-((4,5-Dimethoxy-2-methylphenyl)methyl)-2,4-pyrimidinediamine
Ro 5-9754
component of Rofenaid
Ormetoprim
EINECS 230-246-6
MFCD00057747
2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
5-(4,5-Dimethoxy-2-methylbenzyl)-2,4(1H,3H)-pyrimidinediimine
5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine
2,4(1H,3H)-Pyrimidinediimine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
5-(4,5-Dimethoxy-2-methylbenzyl)-2,4-pyrimidinediamine
Ormethoprim
Ormetorprim
Description Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2].
Related Catalog
In Vivo Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL)[3]. Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration[3]. Animal Model: Hybrid striped bass (565-805 g)[3] Dosage: 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis) Administration: I.p. and p.o. administration Result: I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL. P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%.
References

[1]. Sanders SM, et, al. Sorption of the veterinary antimicrobials sulfadimethoxine and ormetoprim in soil. J Environ Qual. 2008 Jun 23; 37(4): 1510-8.

[2]. Guerard JJ, et, al. Photodegradation of ormetoprim in aquaculture and stream-derived dissolved organic matter. J Agric Food Chem. 2012 Oct 3; 60(39): 9801-6.

[3]. Bakal RS, et, al. Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis). J Vet Pharmacol Ther. 2004 Feb; 27(1): 1-6.
Density 1.3±0.1 g/cm3
Boiling Point 398.2±52.0 °C at 760 mmHg
Melting Point 233°C
Molecular Formula C14H18N4O2
Molecular Weight 274.318
Flash Point 194.6±30.7 °C
Exact Mass 274.142975
PSA 96.28000
LogP 1.13
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.608
Storage condition 0-6°C

Chemsrc provides CAS#:6981-18-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 6981-18-6 | Chemsrc address: https://www.chemsrc.com/en/baike/820848.html

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