514-65-8
514-65-8 structure
- Name: biperiden
- Chemical Name: biperiden
- CAS Number: 514-65-8
- Molecular Formula: C21H29NO
- Molecular Weight: 311.461
- Catalog: API Nervous system medication Anti-shock palsy
- Create Date: 2018-05-13 08:00:00
- Modify Date: 2024-01-02 15:47:57
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Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.Target: M1 receptorsBiperiden is an antiparkinsonian agent of the anticholinergic type. It is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate. It also has a prominent central blocking effect on M1 receptors [2].Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty, whereas biperiden and procyclidine did not [3].Clinical indications: parkinsonismFDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness
| Name | biperiden |
|---|---|
| Synonyms |
Biperidene [INN-French]
1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl- 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol EINECS 208-184-6 1-piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl- Biperideno 1-norborn-5-en-2-yl-1-phenyl-3-piperidino-propan-1-ol Biperidene Biperidine Beperiden a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol biperiden UNII:0FRP6G56LD 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol 1-norborn-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol 3-Piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol Akineton 1-Piperidinepropanol, α-[(1R,4R)-bicyclo[2.2.1]hept-5-en-2-yl]-α-phenyl- 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol 1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol 1-Piperidinepropanol, α-bicyclo(2.2.1)hept-5-en-2-yl-α-phenyl- Biperidenum a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol Biperideno [INN-Spanish] Biperidenum [INN-Latin] 1-[(1R,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-propanol 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(1-piperidinyl)-1-propanol |
| Description | Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.Target: M1 receptorsBiperiden is an antiparkinsonian agent of the anticholinergic type. It is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate. It also has a prominent central blocking effect on M1 receptors [2].Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty, whereas biperiden and procyclidine did not [3].Clinical indications: parkinsonismFDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 462.1±40.0 °C at 760 mmHg |
| Melting Point | 114ºC |
| Molecular Formula | C21H29NO |
| Molecular Weight | 311.461 |
| Flash Point | 224.5±26.0 °C |
| Exact Mass | 311.224915 |
| PSA | 23.47000 |
| LogP | 4.01 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.583 |
| Water Solubility | 25.1 mg/L |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2933399090 |
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |