112398-08-0

112398-08-0 structure

Name: Danofloxacine
Chemical Name: Danofloxacin
CAS Number: 112398-08-0
Molecular Formula: C₁₉H₂₀FN₃O₃
Molecular Weight: 357.379
Catalog: API Synthetic anti-infective drugs Quinolone
Create Date: 2018-07-23 16:55:08
Modify Date: 2024-01-05 12:38:45
Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment[1][2].

Name	Danofloxacin
Synonyms	1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid danofloxacin 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo- 1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1S)-1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinolinecarboxylic acid

Description	Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Erjie Tian, et al. Population Pharmacokinetics for Danofloxacin in the Intestinal Contents of Healthy and Infected Chickens. J Vet Pharmacol Ther. 2019 Sep;42(5):556-563. [2]. Xia Xiao, et al. Comparative Pharmacokinetics of Danofloxacin in Healthy and Pasteurella Multocida Infected Ducks. J Vet Pharmacol Ther. 2018 Dec;41(6):912-918.

Density	1.5±0.1 g/cm3
Boiling Point	569.3±50.0 °C at 760 mmHg
Melting Point	268-272ºC
Molecular Formula	C₁₉H₂₀FN₃O₃
Molecular Weight	357.379
Flash Point	298.1±30.1 °C
Exact Mass	357.148865
PSA	65.78000
LogP	1.20
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.679
Water Solubility	Soluble in water, acetic acid and DMSO

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn,Xi
Risk Phrases	20/21/22-36/37/38
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport

93107-30-3

52321-26-3

~78%

112398-08-0

Precursor 1
93107-30-3
DownStream 0