37321-09-8

37321-09-8 structure

Name: Apramycin
Chemical Name: apramycin
CAS Number: 37321-09-8
Molecular Formula: C₂₁H₄₁N₅O₁₁
Molecular Weight: 539.57700
Catalog: API Antibiotics Cephalosporin
Create Date: 2018-07-03 11:38:19
Modify Date: 2024-01-11 12:07:17
Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.

Name	apramycin
Synonyms	APRAMYCIN el857 EINECS 253-460-1 nebramycinfactor2 el-857/820 apralan ApryMycin ambylan

Description	Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Apramycin, From Wikipedia

WISWESSER LINE NOTATION :: T66 BO GOTJ DM1 EQ IZ CO- BT6OTJ CQ DQ EZ F1Q& HO- BL6TJ AZ CQ DQ EZ

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977

37321-09-8	41194-16-5
410097-64-2	65710-07-8