18010-40-7

18010-40-7 structure

Name: Bupivacaine hydrochloride
Chemical Name: bupivacaine hydrochloride (anhydrous)
CAS Number: 18010-40-7
Molecular Formula: C₁₈H₂₉ClN₂O
Molecular Weight: 324.889
Catalog: Biochemical Inhibitor Transmembrane Transporters Sodium Channel inhibitor
Create Date: 2018-09-17 16:04:11
Modify Date: 2024-01-13 10:04:30
Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.Target: OthersBupivacaine hydrochloride is an effective local anesthetic agent. It has a rapid onset time, a high frequency of surgical anesthesia, a long duration, and a low incidence of side effects [1]. Median doses of bupivacaine (in milligrams per kilogram) producing asystole in protocol 1 were for 17.7 for saline, 27.6 for 10% Intralipid, 49.7 for 20% Intralipid, and 82.0 for 30% Intralipid (P < 0.001 for differences between all groups). Differences in mean +/- SE concentrations of bupivacaine in plasma (in micrograms per milliliter) were significant (P < 0.05) for the difference between saline (93.3 +/- 7.6) and 30% Intralipid (212 +/- 45). In protocol 2, lipid infusion increased the dose of bupivacaine required to cause death in 50% of animals by 48%, from 12.5 to 18.5 mg/kg. The mean lipid:aqueous ratio of concentrations of bupivacaine in a plasma-Intralipid mixture was 11.9 +/- 1.77 (n = 3) [2].

Name	bupivacaine hydrochloride (anhydrous)
Synonyms	Marcaina Bupivacaine hydrochloride Sensorcaine Marcaine Bupivacaine (hydrochloride) 2',6'-Pipecoloxylidide,1-butyl-,monohydrochloride bupivacaine HCl 1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamidhydrochlorid 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide monohydrochloride Einecs 241-917-8 Win 11318 HCl Bupivacaine hydrochloride(Marcain) BUPIVACAINE HYDROCHLORIDE ANHYDROUS UNII:AKA908P8J1 1-butyl-N-(2,6-diméthylphényl)pipéridine-2-carboxamide chlorhydrate bupivacaine monohydrochloride 1-butyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide),hydrochloride 2',6'-Pipecoloxylidide,1-butyl-,hydrochloride (6CI) Marcain 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1) 1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride (1:1) 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, hydrochloride (1:1) Bicain

Description	Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.Target: OthersBupivacaine hydrochloride is an effective local anesthetic agent. It has a rapid onset time, a high frequency of surgical anesthesia, a long duration, and a low incidence of side effects [1]. Median doses of bupivacaine (in milligrams per kilogram) producing asystole in protocol 1 were for 17.7 for saline, 27.6 for 10% Intralipid, 49.7 for 20% Intralipid, and 82.0 for 30% Intralipid (P < 0.001 for differences between all groups). Differences in mean +/- SE concentrations of bupivacaine in plasma (in micrograms per milliliter) were significant (P < 0.05) for the difference between saline (93.3 +/- 7.6) and 30% Intralipid (212 +/- 45). In protocol 2, lipid infusion increased the dose of bupivacaine required to cause death in 50% of animals by 48%, from 12.5 to 18.5 mg/kg. The mean lipid:aqueous ratio of concentrations of bupivacaine in a plasma-Intralipid mixture was 11.9 +/- 1.77 (n = 3) [2].
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References	[1]. Laskin, J.L., W.R. Wallace, and B. DeLeo, Use of bupivacaine hydrochloride in oral surgery-a clinical study. J Oral Surg, 1977. 35(1): p. 25-9. [2]. Weinberg, G.L., et al., Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology, 1998. 88(4): p. 1071-5.