2610-05-1

2610-05-1 structure

Name: Direct Blue 1
Chemical Name: Chicago Sky Blue 6B,6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonicacid]tetrasodiumsalt
CAS Number: 2610-05-1
Molecular Formula: C₃₄H₂₄N₆Na₄O₁₆S₄
Molecular Weight: 992.804
Catalog: Biochemical Biochemical reagent Biological dye
Create Date: 2018-04-24 08:00:00
Modify Date: 2024-01-12 10:47:05
Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].

Name	Chicago Sky Blue 6B,6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonicacid]tetrasodiumsalt
Synonyms	paperblue6b modrprima1 CartaBlue2G Direct Blue 1 Direct Blue 1 Pontamine sky blue 1,3-Naphthalenedisulfonic acid, 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)di-2,1-diazenediyl]bis[4-amino-5-hydroxy-, sodium salt (1:4) Chicago Sky Blue nsb6b Tetrasodium 6,6'-[(3,3'-dimethoxy-4,4'-biphenyldiyl)di-2,1-diazenediyl]bis(4-amino-5-hydroxy-1,3-naphthalenedisulfonate) Chicago Sky Blue 6B Pontamine Sky Blue 6B EINECS 220-026-8 CHICAGO BLUE MFCD00004020 skyblue6b C. I. Direct blue I inkblue6b

Description	Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344. [2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658. [3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

CHEMICAL NAME :: 6,8-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo))bis( 5-amino-4-hydroxy-, tetrasodium salt

WISWESSER LINE NOTATION :: L66J BZ CSWO ESWO JQ INUNR BO1 DR CO1 DNUN- IL66J BZ CSWO ESWO JQ &-NA- 4

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,103,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2162 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1141 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2162 No. of Facilities: 156 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 10195 (estimated) No. of Female Employees: 6491 (estimated)