Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Homatropine
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87-00-3

87-00-3 structure

Name: Homatropine
Chemical Name: [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate
CAS Number: 87-00-3
Molecular Formula: C₁₆H₂₁NO₃
Molecular Weight: 275.34300
Catalog: API Nervous system medication Cholinergic
Create Date: 2018-03-23 08:00:00
Modify Date: 2024-01-02 19:55:33
Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent[1].

Name	[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate
Synonyms	Omatropina [DCIT] Homatropin Homotropine DL-mandelic acid-tropane-3endo-yl ester Homoatropine homatropine Mandelyltropeine Homatropine [BAN] Methylhomatropinum DL-Mandelsaeure-tropan-3endo-ylester EINECS 201-716-8 homatropine hydrobromide 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester Mandelytropeine MFCD00067305

Description	Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
In Vitro	Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs[1]. Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses[2].
In Vivo	Homatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats[3]. Animal Model: Male albino rats[3] Dosage: 9 mm x 5 mm conical suppository Administration: By suppository Result: Blocked cardiovascular responses to vagal stimulation and acetylcholine; 10-20 min after insertion of the suppository the effects of vagal stimulation over a range of 2-16 Hz, 5 V, on pulse rate was virtually abolished and remained unchanged at 45-60 min.

Density	1.21 g/cm3
Boiling Point	403.3ºC
Melting Point	100ºC
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34300
Flash Point	197.7ºC
Exact Mass	275.15200
PSA	49.77000
LogP	1.82630

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM5600000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, mandelate (ester)

CAS REGISTRY NUMBER :: 87-00-3

BEILSTEIN REFERENCE NO. :: 0087959

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H21-N-O3

MOLECULAR WEIGHT :: 275.38

WISWESSER LINE NOTATION :: T56 A ANTJ A1 GOVYQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,156,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1307 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84350 No. of Facilities: 170 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2582 (estimated)

HS Code	2933990090

611-71-2

120-29-6

87-00-3

Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 117, p. 147

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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