480-47-7

480-47-7 structure

Name: Hydrangenol
Chemical Name: hydrangenol
CAS Number: 480-47-7
Molecular Formula: C₁₅H₁₂O₄
Molecular Weight: 256.253
Catalog: Natural product Coumarin
Create Date: 2018-09-29 12:17:32
Modify Date: 2024-01-02 17:15:30
Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].

Name	hydrangenol
Synonyms	3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one Hydrangenol 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-isochromen-1-one 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)- UNII:TL8PI7PHV1 8-Hydroxy-3-(4-hydroxy-phenyl)-isochroman-1-one

Description	Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	MMP-1 MMP-3 COX-2 IL-6
In Vivo	Hydrangenol (5, 10, 20, 或 40 mg/kg; 口服; 每日给药，共 7 周) 减轻 uvb 照射 HR-1 无毛小鼠的皱纹形成、背厚、脱水和胶原蛋白降解[1]。 Animal Model: UVB-irradiated HR-1 hairless mice[1] Dosage: 5, 10, 20, or 40 mg/kg Administration: Oral gavage; daily for 7 weeks Result: Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Increased the expression of Pro-COL1A1. Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6). Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1). Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).
References	[1]. Myung DB, et al. Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice. Nutrients. 2019 Oct 2;11(10):2354.

Density	1.4±0.1 g/cm3
Boiling Point	528.3±50.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₂O₄
Molecular Weight	256.253
Flash Point	206.4±23.6 °C
Exact Mass	256.073547
PSA	66.76000
LogP	2.54
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.662

Hazard Codes	Xi

Precursor 10
82780-51-6 637774-32-4 1093748-41-4 120743-99-9
67600-94-6 4397-53-9 1798-09-0 100-66-3
117970-24-8 118842-88-9
DownStream 3
567-61-3 99-96-7 80458-94-2