73218-79-8

73218-79-8 structure

Name: Iopidine
Chemical Name: apraclonidine hydrochloride
CAS Number: 73218-79-8
Molecular Formula: C₉H₁₁Cl₃N₄
Molecular Weight: 281.56900
Catalog: API Special medicine Ophthalmic medication
Create Date: 2018-09-08 11:28:09
Modify Date: 2024-01-02 18:50:42
Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].

Name	apraclonidine hydrochloride
Synonyms	UNII-D2VW67N38H Iopidine ophthalmic solution MFCD00135922 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine 2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride APRACLONIDINE HYDROCHLORIDE ALO-2145 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine,hydrochloride p-aminoclonidine hydrochloride NC 14 hydrochloride 2-[(2,6-dichloro-4-aminophenyl)imino]imidazolidine hydrochloride p-aminoclonidine mono hydrochloride Apraclonidine HCl

Description	Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2].
In Vivo	Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery[2].
References	[1]. Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132. [2]. Searles RV, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999;58(4):220‐226.

Density	1.63 g/cm3
Boiling Point	395.5ºC at 760 mmHg
Melting Point	>230ºC
Molecular Formula	C₉H₁₁Cl₃N₄
Molecular Weight	281.56900
Flash Point	193ºC
Exact Mass	280.00500
PSA	62.44000
LogP	3.16730
Storage condition	2-8°C
Stability	Moisture Sensitive
Water Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL Solutions may be stored for several days at 4?#x00b0;C

CHEMICAL NAME :: 1,4-Benzenediamine, 2,6-dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%