925705-73-3
925705-73-3 structure
- Name: TG100713
- Chemical Name: 3-(2,4-diaminopteridin-6-yl)phenol
- CAS Number: 925705-73-3
- Molecular Formula: C12H10N6O
- Molecular Weight: 254.247
- Catalog: Biochemical Inhibitor PI3K/Akt/mTOR inhibitor (PI3K/Akt/mTOR) PI3K inhibitor
- Create Date: 2017-07-16 13:21:24
- Modify Date: 2024-01-07 11:17:59
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TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1].
| Name | 3-(2,4-diaminopteridin-6-yl)phenol |
|---|---|
| Synonyms |
cc-655
Phenol, 3-(2,4-diamino-6-pteridinyl)- 3-(2,4-Diamino-6-pteridinyl)phenol Phenol,3-(2,4-diamino-6-pteridinyl) |
| Description | TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
PI3Kδ:24 nM (IC50) PI3Kγ:50 nM (IC50) PI3Kα:165 nM (IC50) PI3Kβ:215 nM (IC50) |
| In Vitro | TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 646.4±65.0 °C at 760 mmHg |
| Molecular Formula | C12H10N6O |
| Molecular Weight | 254.247 |
| Flash Point | 344.8±34.3 °C |
| Exact Mass | 254.091614 |
| PSA | 124.56000 |
| LogP | 0.50 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.815 |