Name | 4,7,10-Trioxa-1,13-Tridecanediamine |
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Synonyms |
4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propan-1-amine 3,3'-[OXYBIS(ETHANE-2,1-DIYLOXY)]DIPROPAN-1-AMINE Diethylene Glycol Bis(3-aMinopropyl) Ether EINECS 224-207-2 MFCD00059850 3,3'-[Oxybis(2,1-ethanediyloxy)]di(1-propanamine) 1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- 3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine) Bis[2-(3-aminopropoxy)ethyl] Ether |
Description | PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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Related Catalog | |
Target |
Alkyl/ether |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 310.6±0.0 °C at 760 mmHg |
Melting Point | -32 °C |
Molecular Formula | C10H24N2O3 |
Molecular Weight | 220.309 |
Flash Point | 148.0±17.4 °C |
Exact Mass | 220.178696 |
PSA | 79.73000 |
LogP | -1.51 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.464 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS05 |
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Signal Word | Danger |
Hazard Statements | H314 |
Precautionary Statements | P280-P305 + P351 + P338-P310 |
Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
Hazard Codes | C: Corrosive; |
Risk Phrases | R34 |
Safety Phrases | S26-S36/37/39-S45 |
RIDADR | UN 2735 8/PG 3 |
WGK Germany | 2 |
RTECS | ID6475000 |
Packaging Group | III |
Hazard Class | 8 |
HS Code | 2922199090 |
~% 4246-51-9 |
Literature: AIR PRODUCTS AND CHEMICALS, INC. Patent: EP1512675 A1, 2005 ; Location in patent: Page/Page column 4-5; 7 ; |
~% 4246-51-9
Detail
|
Literature: AIR PRODUCTS AND CHEMICALS, INC. Patent: EP1512675 A1, 2005 ; Location in patent: Page/Page column 3; 6 ; |
~% 4246-51-9 |
Literature: Chekulaeva,I.A. et al. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1967 , p. 1752 - 1754 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1967 , p. 1829 - 1832 |
~% 4246-51-9 |
Literature: Saggiomo, Vittorio; Luening, Ulrich European Journal of Organic Chemistry, 2008 , # 25 p. 4329 - 4333 |
Precursor 4 | |
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DownStream 7 | |
HS Code | 2922199090 |
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Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |