DC Chemicals Limited
China
Product Name: Paramethadione
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: paramethadione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

115-67-3

115-67-3 structure

115-67-3 structure

Name: paramethadione (500 mg)
Chemical Name: 5-ethyl-3,5-dimethyl-1,3-oxazolidine-2,4-dione
CAS Number: 115-67-3
Molecular Formula: C₇H₁₁NO₃
Molecular Weight: 157.16700
Catalog: API Nervous system medication Antiepileptic and anticonvulsant
Create Date: 2018-03-08 08:00:00
Modify Date: 2024-01-10 16:59:47
Parametadione (Isoethadione) is an antiepileptic agent[1].

Name	5-ethyl-3,5-dimethyl-1,3-oxazolidine-2,4-dione
Synonyms	Parametadione [DCIT] 5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione Paramethadionum Parametadiona Parametadione 5-Ethyl-3,5-dimethyloxazolidine-2,4-dione Paramethadion Parametadiona [INN-Spanish] Isoethadione Paramethadionum [INN-Latin] Paradione EINECS 204-098-8 paramethadione 5-Aethyl-3,5-dimethyl-oxazolidin-2,4-dion 3,5-Dimethyl-5-ethyl-2,4-oxazoldion Paradione (TN)

Description	Parametadione (Isoethadione) is an antiepileptic agent[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Iravani J. Die Wirkung einiger zentral wirksamer Pharmaka auf die synaptische Ubertragung im Krebsmuskel [The effect of some centrally acting drugs on the synaptic transmission in the crayfish muscle]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Aug 20;251(4):375-95.

Density	d425 1.1180-1.1240
Boiling Point	281.82°C (rough estimate)
Molecular Formula	C₇H₁₁NO₃
Molecular Weight	157.16700
Exact Mass	157.07400
PSA	46.61000
LogP	0.70160
Index of Refraction	nD25 1.449

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP9800000

CHEMICAL NAME :: 2,4-Oxazolidinedione, 5-ethyl-3,5-dimethyl-

CAS REGISTRY NUMBER :: 115-67-3

BEILSTEIN REFERENCE NO. :: 0127715

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H11-N-O3

MOLECULAR WEIGHT :: 157.19

WISWESSER LINE NOTATION :: T5OVNV EHJ C1 E2 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,280,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,280,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,126,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - homeostasis

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,126,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 1273 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965

RIDADR	NONH for all modes of transport
HS Code	2934999090

77-78-1 structure

77-78-1

~%

115-67-3 structure

115-67-3

Literature: Journal of the American Chemical Society, , vol. 66, p. 1244 US2575692 , ;

74-88-4 structure

74-88-4

~%

115-67-3 structure

115-67-3

Literature: US2559011 , ; DE834992 , ; DRP/DRBP Org.Chem.

Precursor 2
77-78-1 74-88-4
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%