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142-88-1

142-88-1 structure
142-88-1 structure
  • Name: Piperazine adipate
  • Chemical Name: Piperazine Adipate
  • CAS Number: 142-88-1
  • Molecular Formula: C10H20N2O4
  • Molecular Weight: 232.27700
  • Catalog: API Antiparasitic drug Anthelmintic
  • Create Date: 2018-07-29 18:27:16
  • Modify Date: 2024-01-06 21:32:31
  • Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.

Name Piperazine Adipate
Synonyms PIPERAZINE ADIPATE
hexanedioic acid,piperazine
EINECS 205-569-0
MFCD00050650
Description Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.
Related Catalog
In Vitro Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Piperazine adipate inhibits oxaloacetate reduction by 26% and 55% in A. galli and H. gallinae, resepctively[1].
References

[1]. Sharma RK, et al. Effect of parbendazole and piperazine adipate on the activity of some enzymes of Ascaridia galli and Heterakis gallinae. Vet Parasitol. 1987 May;24(3-4):211-20.

Boiling Point 338.5ºC at 760 mmHg
Melting Point 250ºC (Decomposes)
Molecular Formula C10H20N2O4
Molecular Weight 232.27700
Flash Point 172.7ºC
Exact Mass 232.14200
PSA 98.66000
LogP 0.55280
Vapour Pressure 1.81E-05mmHg at 25°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents. May be light-sensitive.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MO1955000
CAS REGISTRY NUMBER :
142-88-1
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H10-O4.C4-H10-N2
MOLECULAR WEIGHT :
232.32
WISWESSER LINE NOTATION :
T6N DNTJ &QV4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 13,539,1955
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982
RIDADR NONH for all modes of transport
RTECS MO1955000
HS Code 2933599090
HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%