DC Chemicals Limited
China
Product Name: Oxyphenisatine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2H-Indol-2-one,1,3-dihydro-3,3-bis(4-hydroxyphenyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

125-13-3

125-13-3 structure

125-13-3 structure

Name: Oxyphenisatine
Chemical Name: 3,3-bis(4-hydroxyphenyl)-1H-indol-2-one
CAS Number: 125-13-3
Molecular Formula: C₂₀H₁₅NO₃
Molecular Weight: 317.33800
Catalog: API Digestive system medication Laxative antidiarrheal
Create Date: 2018-11-28 20:40:26
Modify Date: 2024-01-02 10:57:49
Oxyphenisatine (Oxyphenisatin) is a laxative. Oxyphenisatin acetate is the pro-drug of oxyphenisatin with anticancer activity.

Name	3,3-bis(4-hydroxyphenyl)-1H-indol-2-one
Synonyms	Phenolisatin Oxyphenisatine Propellax Hoscolax Neodrast 3,3-bis-(4-hydroxy-phenyl)-indolin-2-one EINECS 204-728-1 Veripaque 3,3-bis(4'-hydroxyphenyl)-2-oxo-2,3-dihydroindole Diphenolisatin 3,3-bis-(4-hydroxy-phenyl)-1,3-dihydro-indol-2-one Normalax Oxyphenisatin Isatinbisphenol 3,3-bis-(4-hydroxyphenyl)-2-indolinone

Description	Oxyphenisatine (Oxyphenisatin) is a laxative. Oxyphenisatin acetate is the pro-drug of oxyphenisatin with anticancer activity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Oxyphenisatin has been shown to have antiproliferative activity. Oxyphenisatin acetate (OXY, NSC 59687) is the pro-drug of oxyphenisatin. OXY inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC50=0.8, 0.6, 2.1, 1.8 μM). This effect is associated with selective inhibition of translation accompanied by rapid phosphorylation of the nutrient sensing eIF2α kinases, GCN2 and PERK[1].
In Vivo	Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52[1].
Animal Admin	Mice: When tumors reaches 120 mg, mice are randomized into treatment groups and therapy is initiated. Asimple toxicity assessment to determine tolerability to OXY is conducted by administering single intraperitoneal (IP) doses of compound at 100, 200, and 400 mg/kg. The mice were observed for adverse effects for 14 days postdose[1].
References	[1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700.

Density	1.352g/cm3
Boiling Point	562.9ºC at 760 mmHg
Molecular Formula	C₂₀H₁₅NO₃
Molecular Weight	317.33800
Flash Point	294.2ºC
Exact Mass	317.10500
PSA	69.56000
LogP	3.52230
Vapour Pressure	2.82E-13mmHg at 25°C
Index of Refraction	1.691
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2083780

CHEMICAL NAME :: 2-Indolinone, 3,3-bis(p-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 125-13-3

BEILSTEIN REFERENCE NO. :: 0286070

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H15-N-O3

MOLECULAR WEIGHT :: 317.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 300 ug/kg/36H-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - jaundice, other or unclassified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 285,813,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 214 ug/kg/1D

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - jaundice, other or unclassified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 285,813,1971

HS Code	2933790090

91-56-5 structure

91-56-5

108-95-2 structure

108-95-2

~90%

125-13-3 structure

125-13-3

Literature: Song, Hyun Nam; Lee, Hong Jung; Kim, Hyoung Rae; Ryu, Eung K.; Kim, Jae Nyoung Synthetic Communications, 1999 , vol. 29, # 19 p. 3303 - 3311

91-56-5 structure

91-56-5

122-79-2 structure

122-79-2

108-95-2 structure

108-95-2

~%

125-13-3 structure

125-13-3

Literature: Woelm Fabr. Chem.-Pharm. Praep. Patent: DE824203 , 1948 ;

39033-45-9 structure

39033-45-9

108-95-2 structure

108-95-2

~%

125-13-3 structure

125-13-3

Literature: Inagaki Yakugaku Zasshi, 1933 , vol. 53, p. 686,696;dtsch.Ref.S.133 Chem. Zentralbl., 1933 , vol. 104, # II p. 2133

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%