74844-91-0

74844-91-0 structure

Name: Boc-Hyp-OMe
Chemical Name: N-Boc-trans-4-Hydroxy-L-proline methyl ester
CAS Number: 74844-91-0
Molecular Formula: C₁₁H₁₉NO₅
Molecular Weight: 245.272
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2018-02-18 08:00:00
Modify Date: 2024-01-02 15:40:13
Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Name	N-Boc-trans-4-Hydroxy-L-proline methyl ester
Synonyms	(2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester N-BOC-transydro-L-prolinemethylester 1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER N-BOC-L-Hydroxyproline methyl ester 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate BOC-HYDROXYPROLINE-OME N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester BOC-L-4-HYDROXYPROLINE METHYL ESTER N-Boc-trans-hydro-L-prolinemethylester N-Boc-cis-4-Hydroxy-L-prolinem ethylester N-Boc-trans-4-Hydroxy-L-prolinemethylester Boc-Hyp-Ome (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate MFCD00076981 BOC-L-HYDROXYPROLINE METHYL ESTER BOC-L-T-4-HYDROXYPROLINE METHYL ESTER Boc-trans-4-hydroxy-L-proline methyl ester N-Boc-cis-4-hydroxy-L-proline methyl ester Boc-cis-Hyp-OMe cis-Boc-Hyp-OMe

Description	Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%