Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tributyl citrate
Price: ￥78.0/500ml
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tributyl citrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tributyl Citrate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

77-94-1

77-94-1 structure

Name: Tributyl citrate
Chemical Name: Tributyl citrate
CAS Number: 77-94-1
Molecular Formula: C₁₈H₃₂O₇
Molecular Weight: 360.45
Catalog: Chemical reagent Organic reagent Borate
Create Date: 2018-02-06 08:00:00
Modify Date: 2024-01-02 17:19:52
Tributyl citrate is a citric acid ester. Tributyl citrate can be used as an excipient, such as plasticizer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

Name	Tributyl citrate
Synonyms	1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tributyl ester Tri-n-butyl citrate Citric acid tri-n-butyl ester EINECS 201-071-2 MFCD00027217 Citric acid, tributyl ester (8CI) Tributyl citrate tributyl 2-hydroxypropane-1,2,3-tricarboxylate

Description	Tributyl citrate is a citric acid ester. Tributyl citrate can be used as an excipient, such as plasticizer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. FINKELSTEIN M, et al. Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate. Toxicol Appl Pharmacol. 1959 May;1(3):283-98. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Density	1.1±0.1 g/cm3
Boiling Point	389.8±9.0 °C at 760 mmHg
Melting Point	≥300 °C(lit.)
Molecular Formula	C₁₈H₃₂O₇
Molecular Weight	360.45
Flash Point	120.7±12.2 °C
Exact Mass	360.214813
PSA	99.13000
LogP	4.68
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.465
Water Solubility	insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ8608000

CHEMICAL NAME :: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tributyl ester

CAS REGISTRY NUMBER :: 77-94-1

BEILSTEIN REFERENCE NO. :: 1806072

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H32-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - other changes

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8120 mg/kg/14D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964

Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	S26-S36/37/39-S45-S24/25
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	TZ8608000
HS Code	2918150000

77-92-9

71-36-3

~94%

77-94-1

Literature: Sakakura, Akira; Nakagawa, Shoko; Ishihara, Kazuaki Tetrahedron, 2006 , vol. 62, # 2-3 p. 422 - 433

77-92-9

71-36-3

118068-28-3

142-96-1

Detail

Literature: EP1849764 A1, ; Page/Page column 21-22 ;

298-12-4

71-36-3

105-76-0

2050-60-4

Detail

Literature: Chemistry and Biodiversity, , vol. 9, # 4 p. 714 - 726

7664-93-9

77-92-9

71-36-3

77-94-1

Literature: Industrial and Engineering Chemistry, , vol. 47, p. 797

Precursor 4
77-92-9 71-36-3 298-12-4 7664-93-9
DownStream 2
77-90-7 16544-70-0

HS Code	2918150000
Summary	2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

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