2241019-57-6
2241019-57-6 structure
- Name: NAMPT inhibitor-linker 1
- Chemical Name: NAMPT inhibitor-linker 1
- CAS Number: 2241019-57-6
- Molecular Formula: C36H37FN6O6
- Molecular Weight: 668.71
- Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
- Create Date: 2019-03-03 10:07:07
- Modify Date: 2024-01-11 10:55:01
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NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.
| Name | NAMPT inhibitor-linker 1 |
|---|
| Description | NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively. |
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| Related Catalog | |
| In Vitro | ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pM and 9 pM, respectively[1]. |
| In Vivo | ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1]. Animal Model: Female scid-beige (SCID bg) mice[1] Dosage: 20 mg/kg Administration: A single intravenous injection (i.v.) for 28 days Result: Significantly inhibited the growth of tumor in mice. |
| References |
| Molecular Formula | C36H37FN6O6 |
|---|---|
| Molecular Weight | 668.71 |