CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UC8045000
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CHEMICAL NAME :
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Propene, 1-chloro-2-methyl-
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CAS REGISTRY NUMBER :
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513-37-1
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BEILSTEIN REFERENCE NO. :
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1733843
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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24
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MOLECULAR FORMULA :
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C4-H7-Cl
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MOLECULAR WEIGHT :
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90.56
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WISWESSER LINE NOTATION :
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G1UY1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4465 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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400 mg/m3/4H
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3160 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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181 gm/m3
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TOXIC EFFECTS :
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Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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17500 mg/kg/14D-I
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TOXIC EFFECTS :
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Behavioral - muscle weakness Musculoskeletal - other changes Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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48750 mg/kg/13W-I
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Gastrointestinal - necrotic changes Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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14 gm/kg/14D-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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48750 mg/kg/13W-I
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TOXIC EFFECTS :
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Blood - changes in spleen Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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51500 mg/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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51 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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102 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
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Heritable translocation test
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Ovary
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DOSE/DURATION :
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500 mg/L
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-316,1986 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,315,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,315,1995 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,315,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993
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