32619-42-4

32619-42-4 structure

Name: Oleuropein
Chemical Name: Oleuropein
CAS Number: 32619-42-4
Molecular Formula: C₂₅H₃₂O₁₃
Molecular Weight: 540.514
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-05-17 08:00:00
Modify Date: 2024-01-02 10:51:00
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].

Name	Oleuropein
Synonyms	Olive Leaf Extract MFCD00017493 Oleuropein oleuropein glucoside EINECS 251-129-6 Methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-2H-pyran-5-carboxylate 2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, (2S,3E,4S)-

Description	Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Signaling Pathways >> Others >> Aromatase
Target	PPARγ Apoptosis Aromatase
In Vitro	Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy[2].
References	[1]. Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376. [2]. Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	2938909090

Precursor 0
DownStream 2
10597-60-1 178600-68-5

HS Code	2938909090