75217-63-9

75217-63-9 structure

Name: (Met(O)27)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt
Chemical Name: (Met(O)27)-Glucagon (1-29) (human, rat, porcine)
CAS Number: 75217-63-9
Molecular Formula: C₁₅₃H₂₂₅N₄₃O₅₀S
Molecular Weight: 3498.747
Catalog: API Hormone and endocrine-regulating drugs Pancreatic hormones and other blood sugar regulating drugs
Create Date: 2019-01-23 21:48:50
Modify Date: 2024-01-11 17:35:31
(Met(O)27)-Glucagon (1-29) (human, rat, porcine) is a modified glucagon. (Met(O)27)-Glucagon (1-29) (human, rat, porcine) has the same maximum glucose-synthesizing activity in rat hepatocytes as native glucagon, but it is less potent, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor[1].

Name	(Met(O)27)-Glucagon (1-29) (human, rat, porcine)
Synonyms	L-Leucinamide, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arg inyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-N-[(1S)-1-[[[(1S)-3-amino-1-[[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl ]-3-(methylsulfinyl)propyl]- HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

Description	(Met(O)27)-Glucagon (1-29) (human, rat, porcine) is a modified glucagon. (Met(O)27)-Glucagon (1-29) (human, rat, porcine) has the same maximum glucose-synthesizing activity in rat hepatocytes as native glucagon, but it is less potent, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor[1].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. Nooijen WJ, et al. Immunogenicity and bioactivity of glucagon, modified at methionine-27. Horm Metab Res. 1979 Aug;11(8):459-63.