19983-44-9
19983-44-9 structure
- Name: Stattic
- Chemical Name: 6-nitro-1-benzothiophene 1,1-dioxide
- CAS Number: 19983-44-9
- Molecular Formula: C8H5NO4S
- Molecular Weight: 211.195
- Catalog: Biochemical Inhibitor Tyrosine protein kinase/signal transducer and transcriptional activator inhibitor (JAK/STAT) STAT inhibitor
- Create Date: 2018-12-29 10:49:43
- Modify Date: 2024-01-04 14:34:20
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Stattic is a potent inhibitor of STAT3 activation and dimerization.
| Name | 6-nitro-1-benzothiophene 1,1-dioxide |
|---|---|
| Synonyms |
6-Nitro-benzo<b>thiophen-1,1-dioxid
6-nitro-benzo[b]thiophene-1,1-dioxide Benzo[b]thiophene, 6-nitro-, 1,1-dioxide 6-nitro-1H-1λ-benzo[b]thiophene-1,1-dione 6-nitro-1 STAT3 Inhibitor V,Stattic Benzo[b]thiophene,6-nitro-,1,1-dioxide 6-Nitrobenzo[b]thiophene-1,1-dioxide,Stat three inhibitory compound 6-Nitro-1-benzothiophene 1,1-dioxide 6-nitro-1-benzothiophene-1,1-dioxide Stattic Stat three inhibitory compound |
| Description | Stattic is a potent inhibitor of STAT3 activation and dimerization. |
|---|---|
| Related Catalog | |
| Target |
STAT3 |
| In Vitro | Stattic inhibits STAT3 phosphorylation (Y705) in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines at a higher concenration (20 μM). Stattic selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in both ALDH+ and CD44+/CD24+ subpopulations of Panc-1 and HPAC. Stattic inhibita STAT3 downstream targets in ALDH+ and CD44+/CD24+ subpopulations of pancreatic cancer cells[1]. Stattic reduces the LPS-induced expression of ICAM-1 and VCAM-1, and STAT3 phosphorylation[2]. |
| Cell Assay | Pancreatic cancer stem-like cells (3,000/well in 96-well plates) are incubated with desired concentrations of compounds in triplicate at 37˚C for 72 h. MTT viability assays are done and the absorbance is read at 595 nm. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 461.1±45.0 °C at 760 mmHg |
| Melting Point | 184ºC |
| Molecular Formula | C8H5NO4S |
| Molecular Weight | 211.195 |
| Flash Point | 232.6±28.7 °C |
| Exact Mass | 210.993927 |
| PSA | 88.34000 |
| LogP | 1.31 |
| Appearance | white to beige |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.671 |
| Storage condition | Store at +4°C |
| Water Solubility | DMSO: >20mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant;Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 26-36/37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2934999090 |
|
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| Literature: WO2006/36024 A1, ; Page/Page column 154-155 ; |
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| Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943 |
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| Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943 |
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| Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943 |
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| Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943 |
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19983-44-9 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 963 - 968 |
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| Literature: Journal of the Chemical Society, , p. 1615,1617 |
| Precursor 6 | |
|---|---|
| DownStream 3 | |
![6-Amino-2,3-dihydrobenzo[b]thiophene 1,1-dioxide structure](https://www.chemsrc.com/caspic/015/20503-39-3.png)
![6-AMINO-1H-1LAMBDA-6-BENZO[B]THIOPHENE-1,1-DIONE structure](https://www.chemsrc.com/caspic/160/20503-40-6.png)
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |