111358-88-4

111358-88-4 structure

Name: Lestaurtinib
Chemical Name: Lestaurtinib
CAS Number: 111358-88-4
Molecular Formula: C₂₆H₂₁N₃O₄
Molecular Weight: 439.463
Catalog: API Antineoplastic agents Tinic antineoplastic agents
Create Date: 2018-09-22 15:44:20
Modify Date: 2024-01-05 19:22:41
Lestaurtinib (CEP-701;KT-5555) is a multi-kinase inhibitor with potent activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibits JAK2, FLT3 and TrkA with IC50s of 0.9, 3 and less than 25 nM, respectively.

Name	Lestaurtinib
Synonyms	SP 924 Lestaurtinib KT 5555 CEP-701 hydrate CEP-701 (15S,16S,18R)-16-Hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1.0.0.0.0.0]octacosa-1,6,8,10,12,20,22,24,26-nonaen-3-one UNII-DO989GC5D1 6,9-Epoxy-15H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-15-one, 6,7,8,9,16,17-hexahydro-7-hydroxy-7-(hydroxymethyl)-6-methyl-, (6S,7S,9R)-

Description	Lestaurtinib (CEP-701;KT-5555) is a multi-kinase inhibitor with potent activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibits JAK2, FLT3 and TrkA with IC50s of 0.9, 3 and less than 25 nM, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor
Target	JAK2:0.9 nM (IC50) TrkA:25 nM (IC50) FLT3:3 nM (IC50)
References	[1]. Miknyoczki SJ, et al. The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness. Ann N Y Acad Sci. 1999 Jun 30;880:252-62.

Density	1.7±0.1 g/cm3
Boiling Point	723.0±60.0 °C at 760 mmHg
Melting Point	215-220ºC
Molecular Formula	C₂₆H₂₁N₃O₄
Molecular Weight	439.463
Flash Point	391.0±32.9 °C
Exact Mass	439.153198
PSA	88.65000
LogP	3.37
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.880
Storage condition	Desiccate at -20°C
Stability	Photosensitive
Water Solubility	DMSO: >10mg/mL

99533-80-9

~81%

111358-88-4

Literature: Gingrich, Diane E.; Hudkins, Robert L. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2829 - 2831 Title/Abstract Full Text View citing articles Show Details Gingrich, Diane E.; Yang, Shi X.; Gessner, George W.; Angeles, Thelma S.; Hudkins, Robert L. Journal of Medicinal Chemistry, 2005 , vol. 48, # 11 p. 3776 - 3783

Precursor 1
99533-80-9
DownStream 0

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