- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Boc-11-aminoundecanoic acid
- Price: ￥156.0/1g ￥506.0/5g ￥946.0/10g ￥1936.0/25g
- Purity: 95.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Boc-11-Amino undecanoic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
10436-25-6
10436-25-6 structure
- Name: Boc-11-aminoundecanoic acid
- Chemical Name: Boc-11-aminoundecanoic acid
- CAS Number: 10436-25-6
- Molecular Formula: C16H31NO4
- Molecular Weight: 301.42200
- Catalog: Flavors and spices Synthetic spice Alcoholic spice Acyclic aliphatic alcohol
- Create Date: 2018-06-07 13:26:32
- Modify Date: 2024-01-02 22:09:16
-
Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1].
| Name | Boc-11-aminoundecanoic acid |
|---|---|
| Synonyms |
11-((tert-Butoxycarbonyl)amino)undecanoic acid
11-[(2-methylpropan-2-yl)oxycarbonylamino]undecanoic acid MFCD00076902 |
| Description | Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
| Melting Point | 68 °C |
|---|---|
| Molecular Formula | C16H31NO4 |
| Molecular Weight | 301.42200 |
| Exact Mass | 301.22500 |
| PSA | 75.63000 |
| LogP | 4.49750 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2924199090 |
|
~98%
10436-25-6 |
| Literature: Amara, Neri; Mashiach, Roi; Amar, Dotan; Krief, Pnina; Spieser, Stephane A. H.; Bottomley, Matthew J.; Aharoni, Amir; Meijler, Michael M. Journal of the American Chemical Society, 2009 , vol. 131, # 30 p. 10610 - 10619 |
|
~92%
10436-25-6 |
| Literature: JOHNSON, Michael, R. Patent: WO2006/23573 A2, 2006 ; Location in patent: Page/Page column 44 ; WO 2006/023573 A2 |
|
~79%
10436-25-6 |
| Literature: Leydet, Alain; Barragan, Veronique; Boyer, Bernard; Montero, Jean Louis; Roque, Jean Pierre; Witvrouw, Myriam; Este, Jose; Snoeck, Robert; Andrei, Graciela; De Clercq, Erick Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 342 - 349 |
| Precursor 3 | |
|---|---|
| DownStream 1 | |
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |