Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isovanillin
Price: ￥108.0/25g ￥318.0/100g ￥118.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Isovanillin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isovanillin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Iso vanilin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

621-59-0

621-59-0 structure

621-59-0 structure

Name: Isovanillin
Chemical Name: Isovanillin
CAS Number: 621-59-0
Molecular Formula: C₈H₈O₃
Molecular Weight: 152.147
Catalog: Chemical reagent Organic reagent Aromatic aldehyde (containing acetal, hemiacetal)
Create Date: 2018-07-11 11:00:39
Modify Date: 2024-01-02 15:19:58
Isovanillin is an aldehyde oxidase inhibitor[1]. Antispasmodic activities[2]. Antidiarrheal activities[3].

Name	Isovanillin
Synonyms	Benzaldehyde, 3-hydroxy-4-methoxy- 4-MeO-3-OHC6H3CHO 3-hydroxy-4-methoxy-benzaldehyde Isovanillin ISOVANILIN 3-Hydroxy-p-anisaldehyde 4-08-00-01764 (Beilstein Handbook Reference) Isovanilline p-Anisaldehyde, 3-hydroxy- (8CI) 3-Hydroxy-4-methoxybenzolcarbaldehyd 3-Hydroxy-4-methoxybenzaldehyde 4-methoxy-3-hydroxybenzaldehyde EINECS 210-694-9 p-Anisaldehyde, 3-hydroxy- VHR CQ DO1 Isovanicaline MFCD00003369 5-Formylguaiacol iso-vanillin Isovanilllin

Description	Isovanillin is an aldehyde oxidase inhibitor[1]. Antispasmodic activities[2]. Antidiarrheal activities[3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Phenols
Target	Aldehyde oxidase[1]
In Vitro	Isovanillin is not a substrate for aldehyde oxidase and therefore it is metabolized to isovanillic acid predominantly by aldehyde dehydrogenase[1]. Isovanillin is relaxant of ileum contractions induced by 5-HT (IC50=356±50μM) [2].
In Vivo	Isovanillin (2 mg/kg & 5 mg/kg) and iso-acetovanillon (2 mg/kg & 5 mg/kg) both have antidiarrheal and anti-motility effect on gastrointestinal tract[3].
References	[1]. Panoutsopoulos GI, et al. Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared Guinea pig liver slices. Cell Physiol Biochem. 2005;15(1-4):89-98. [2]. Sadraei H, et al. Antispasmodic activity of isovanillin and isoacetovanillon in comparison with Pycnocycla spinosa Decne.exBoiss extract on rat ileum. Res Pharm Sci. 2014 May-Jun;9(3):187-92. [3]. Sadraei H, et al. Antidiarrheal activities of isovanillin, iso-acetovanillon and Pycnocycla spinosa Decne ex.Boiss extract in mice. Res Pharm Sci. 2014 Mar-Apr;9(2):83-9.

Density	1.2±0.1 g/cm3
Boiling Point	308.1±0.0 °C at 760 mmHg
Melting Point	113-116 °C
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	119.9±15.3 °C
Exact Mass	152.047348
PSA	46.53000
LogP	1.10
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.588
Storage condition	-20°C Freezer, Under Inert Atmosphere

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU6540000

CHEMICAL NAME :: Benzaldehyde, 3-hydroxy-4-methoxy-

CAS REGISTRY NUMBER :: 621-59-0

BEILSTEIN REFERENCE NO. :: 1073021

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: VHR CQ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1276 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CU6540000
HS Code	29124900

Precursor 10
4383-06-6 139-85-5 74-88-4 6346-05-0
18075-40-6 145654-01-9 120-57-0 97315-18-9
5779-98-6 111394-51-5
DownStream 9
110815-90-2 105728-94-7 111436-61-4 111394-51-5
4579-60-6 37687-57-3 52805-46-6 34123-66-5
324763-39-5

HS Code	2912499000
Summary	2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%