162831-31-4

162831-31-4 structure

Name: IEM 1754 2HBr
Chemical Name: 1,5-Pentanediamine, N1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrobromide
CAS Number: 162831-31-4
Molecular Formula: C₁₆H₃₂Br₂N₂
Molecular Weight: 412.25
Catalog: Biochemical Inhibitor Neuronal Signaling GluR inhibitor
Create Date: 2016-11-30 22:26:01
Modify Date: 2024-01-05 12:15:18
IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].

Name	1,5-Pentanediamine, N1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrobromide
Synonyms	1,5-Pentanediamine, N-(tricyclo[3.3.1.1]dec-1-ylmethyl)-, hydrobromide (1:2) N-(Adamantan-1-ylmethyl)-1,5-pentanediamine dihydrobromide IEM 1754 2HBr IEM 1754 Dihydrobromide

Description	IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
References	[1]. Tikhonov DB, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74. [2]. Lukomskaia NIa, et al. [Comparison of the anticonvulsant activity of organic mono- and di-cations and their potential to inhibit NMDA and AMPA glutamate receptors]. Ross Fiziol Zh Im I M Sechenova. 2002 Sep;88(9):1161-71. Russian.