Name | Gestodene |
---|---|
Synonyms |
(17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one
SH B 331 GESTOGENE (8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one SH B 33 Femodene EINECS 262-145-8 Gestodene GESTODONE 17a-Ethynyl-13-ethyl-17b-hydroxy-4,15-gonadien-3-one SHG 415 G 17a-Ethynyl-17b-hydroxy-18-methyl-4,15-estradien-3-one Gynovin MFCD00867858 |
Description | Gestodene(SHB 331;WL 70) is a progestogen hormonal contraceptive.Target: Estrogen Receptor/ERRGestodene is androgenically neutral, meaning that contraceptive pills containing gestodene do not exhibit the androgenic side effects (e.g. acne, hirsutism, weight gain) often associated with second-generation contraceptive pills, such as those containing levonorgestrel. When 40 micrograms of gestodene was taken, six out of seven women did not ovulate, and one out of seven had a cycle with luteal insufficiency. These data indicate that 40 micrograms of gestodene is the borderline dose for inhibition of ovulation. A combination of 75 micrograms gestodene with 30 micrograms ethinyl estradiol was found to inhibit ovulation in ten subjects, and no follicular maturation was noted [1]. gestodene bound with high affinity to the progesterone receptor, as did other synthetic and natural progestogens. However, gestodene did not bind to the estradiol receptor. The relative binding affinities of all tested synthetic and natural ligands showed no organ-specific differences and no differences between neoplastically transformed and normal tissues [2].Clinical indications: Female contraception |
---|---|
Related Catalog | |
References |
Density | 1.2±0.1 g/cm3 |
---|---|
Boiling Point | 462.7±45.0 °C at 760 mmHg |
Melting Point | 190-192°C |
Molecular Formula | C21H26O2 |
Molecular Weight | 310.430 |
Flash Point | 196.9±21.3 °C |
Exact Mass | 310.193268 |
PSA | 37.30000 |
LogP | 3.65 |
Vapour Pressure | 0.0±2.6 mmHg at 25°C |
Index of Refraction | 1.588 |
Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS08 |
---|---|
Signal Word | Warning |
Hazard Statements | H361 |
Precautionary Statements | P280 |
Hazard Codes | Xn |
Risk Phrases | 62 |
Safety Phrases | S22-S36/37 |
RIDADR | NONH for all modes of transport |
Precursor 10 | |
---|---|
DownStream 0 |