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77472-70-9

77472-70-9 structure
77472-70-9 structure
  • Name: Carphedon
  • Chemical Name: 2-(2-Oxo-4-phenylpyrrolidin-1-yl)acetamide
  • CAS Number: 77472-70-9
  • Molecular Formula: C12H14N2O2
  • Molecular Weight: 218.252
  • Catalog: Organic raw materials Amino compound Oxy-containing amino compound
  • Create Date: 2018-07-15 14:16:52
  • Modify Date: 2024-01-02 15:45:39
  • Phenylpiracetam(Phenotropyl; Phenotropil) is a phenylated derivative of the nootropic drug piracetam. It is used as a stimulant nootropic drug that can be up to 30-60 times more potent than piracetam.IC50 Value:Target: AMPA receptor allosteric modulatorin vitro: N/Ain vivo: In the open-field test, a significant increase in locomotor activity was observed after a single administration of R-phenotropil at doses of 10 and 50 mg/kg and S-phenotropil at a dose of 50 mg/kg. In the forced swim test, R-phenotropil induced an antidepressant effect at doses of 100 and 50 mg/kg, and S-phenotropil was active at a dose of 100 mg/kg. R-phenotropil significantly enhanced memory function in a passive avoidance response test at a dose of 1 mg/kg; the S-enantiomer did not show any activity in this test [1].
Name 2-(2-Oxo-4-phenylpyrrolidin-1-yl)acetamide
Synonyms fonturacetam
UNII:99QW5JU66Y
Carphedon
Phenylpiracetam
4-Phenyl-2-pyrrolidone-1-acetamide
2-(2-Oxo-4-phenyl-1-pyrrolidinyl)acetamide
1-Pyrrolidineacetamide, 2-oxo-4-phenyl-
2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide
4-Phenylpiracetam
Phenotropil
Description Phenylpiracetam(Phenotropyl; Phenotropil) is a phenylated derivative of the nootropic drug piracetam. It is used as a stimulant nootropic drug that can be up to 30-60 times more potent than piracetam.IC50 Value:Target: AMPA receptor allosteric modulatorin vitro: N/Ain vivo: In the open-field test, a significant increase in locomotor activity was observed after a single administration of R-phenotropil at doses of 10 and 50 mg/kg and S-phenotropil at a dose of 50 mg/kg. In the forced swim test, R-phenotropil induced an antidepressant effect at doses of 100 and 50 mg/kg, and S-phenotropil was active at a dose of 100 mg/kg. R-phenotropil significantly enhanced memory function in a passive avoidance response test at a dose of 1 mg/kg; the S-enantiomer did not show any activity in this test [1].
Related Catalog
References

[1]. Zvejniece L, et al. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):407-12.
Density 1.2±0.1 g/cm3
Boiling Point 486.4±45.0 °C at 760 mmHg
Molecular Formula C12H14N2O2
Molecular Weight 218.252
Flash Point 247.9±28.7 °C
Exact Mass 218.105530
PSA 64.39000
LogP 0.16
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.580

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9663000
CHEMICAL NAME :
1-Pyrrolidineacetamide, 2-oxo-4-phenyl-
CAS REGISTRY NUMBER :
77472-70-9
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H14-N2-O2
MOLECULAR WEIGHT :
218.28
WISWESSER LINE NOTATION :
T5NVTJ A1VZ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,776,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Behavioral - analgesia
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 44,22,1981
HS Code 2933990090
70291-40-6 structure

70291-40-6

~99%

77472-70-9 structure

77472-70-9
Literature: Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48
68497-63-2 structure

68497-63-2

~81%

77472-70-9 structure

77472-70-9
Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
1198-97-6 structure

1198-97-6

~%

77472-70-9 structure

77472-70-9
Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
106869-48-1 structure

106869-48-1

~%

77472-70-9 structure

77472-70-9
Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
3060-41-1 structure

3060-41-1

~%

77472-70-9 structure

77472-70-9
Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979
77519-55-2 structure

77519-55-2

~%

77472-70-9 structure

77472-70-9
Literature: Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48
55790-17-5 structure

55790-17-5

~%

77472-70-9 structure

77472-70-9
Literature: Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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