778576-62-8

778576-62-8 structure

Name: Oglemilast
Chemical Name: N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide
CAS Number: 778576-62-8
Molecular Formula: C₂₀H₁₃Cl₂F₂N₃O₅S
Molecular Weight: 516.30
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Chloropyridine
Create Date: 2017-05-08 12:12:52
Modify Date: 2024-01-06 10:38:49
Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.IC50 value:Target: PDE4

Name	N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide
Synonyms	Oglemilast [INN] N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide Oglemilast UNII-67GXQ6WCC6 4-Methoxy-2-indanamine 1H-Inden-2-amine, 2,3-dihydro-4-methoxy- GRC3886

Description	Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.IC50 value:Target: PDE4
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. [2]. Study of Oglemilast for the Prevention of Asthma. [3]. Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD) [4]. Study of Oglemilast for the Treatment of Asthma