896705-16-1

896705-16-1 structure

Name: BMH 21
Chemical Name: N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
CAS Number: 896705-16-1
Molecular Formula: C₂₁H₂₀N₄O₂
Molecular Weight: 360.409
Catalog: Biochemical Inhibitor DNA damage DNA/RNA Synthesis inhibitor
Create Date: 2017-09-10 17:24:10
Modify Date: 2024-01-02 12:17:27
BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.IC50 value: 10-90 nM(RPA195 IC50) [1]Target: RNA Pol I inhibitorin vitro: BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress [1].

Name	N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Synonyms	N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide 12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo- BMH-21 BMH21

Description	BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.IC50 value: 10-90 nM(RPA195 IC50) [1]Target: RNA Pol I inhibitorin vitro: BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress [1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer
References	[1]. Colis L, et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014 Jun 30;5(12):4361-9. [2]. Colis L, et al. Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J Med Chem. 2014 Jun 12;57(11):4950-61. [3]. Peltonen K, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₁H₂₀N₄O₂
Molecular Weight	360.409
Exact Mass	360.158630
PSA	66.71000
LogP	1.57
Appearance	light yellow to dark yellow
Index of Refraction	1.668
Storage condition	2-8°C
Water Solubility	DMSO: soluble1mg/mL, clear (warmed)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport

108-00-9

63127-04-8

~56%

896705-16-1

2942-59-8

896705-16-1

5959-52-4

896705-16-1

Precursor 4
108-00-9 63127-04-8 2942-59-8 5959-52-4
DownStream 0