Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-tert-Octylphenol
Price: ￥148.0/500g
Purity: 97.0%
Stocking Period: 1 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-tert-Octylphenol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-tert-Octylphenol 140-66-9
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

140-66-9

140-66-9 structure

Name: 4-tert-Octylphenol
Chemical Name: 4-tert-Octylphenol
CAS Number: 140-66-9
Molecular Formula: C₁₄H₂₂O
Molecular Weight: 206.324
Catalog: Organic raw materials Alcohols, phenols, phenolic compounds and derivatives Phenol and its halogenated, sulfonated, nitrated or nitrosated derivatives
Create Date: 2018-05-09 08:00:00
Modify Date: 2024-01-02 12:50:31
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic drug. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice[1].

Name	4-tert-Octylphenol
Synonyms	Phenol, 4-(1,1,3,3-tetramethylbutyl)- 4-(tert-octyl)phenol 4-tert-octyl phenol Phenol, p- (1,1,3,3-tetramethylbutyl)- 4-(2,4,4-trimethylpentan-2-yl)phenol EINECS 205-426-2 Phenol, 4- (1,1,3,3-tetramethylbutyl)- 4-(1,1,3,3-TetraMethylbutyl)phenol p-(Tert-octyl)-Phenol p-tert-octylphenol 4-(2,4,4-Trimethyl-2-pentanyl)phenol p-(1,1,3,3-tetramethylbutyl)phenol MFCD00002368 tert-octylphenol t-octylphenol phenol, 4-tert-octyl- 4-tert-octylphenol para-tert-Octylphenol Phenol, p-(tert-octyl)- p-tert octylphenol（PTOP）

Description	4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic drug. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Endocrinology Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
References	[1]. Dinh Nam Tran, et al. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions. Oxidative Medicine and Cellular Longevity, 2020.

Density	0.9±0.1 g/cm3
Boiling Point	282.3±0.0 °C at 760 mmHg
Melting Point	79-82 °C(lit.)
Molecular Formula	C₁₄H₂₂O
Molecular Weight	206.324
Flash Point	148.3±8.2 °C
Exact Mass	206.167068
PSA	20.23000
LogP	4.93
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.501
Storage condition	Refrigerator
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM9625000

CHEMICAL NAME :: Phenol, p-(1,1,3,3-tetramethylbutyl)-

CAS REGISTRY NUMBER :: 140-66-9

BEILSTEIN REFERENCE NO. :: 0513992

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C14-H22-O

MOLECULAR WEIGHT :: 206.36

WISWESSER LINE NOTATION :: QR DX1&1&1X1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,228,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,228,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Liver - other changes

REFERENCE :: KCRZAE Kauchuk i Rezina. Crude and Vulcanized Rubber. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11- 1937- Volume(issue)/page/year: 26(9),28,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3210 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes Liver - other changes

REFERENCE :: KCRZAE Kauchuk i Rezina. Crude and Vulcanized Rubber. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11- 1937- Volume(issue)/page/year: 26(9),28,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0527972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 894 mg/kg/31W-I

TOXIC EFFECTS :: Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0527972 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5280 mg/kg/12W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1842 No. of Facilities: 516 (estimated) No. of Industries: 6 No. of Occupations: 12 No. of Employees: 15351 (estimated) No. of Female Employees: 736 (estimated)

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319-H336
Supplemental HS	Repeated exposure may cause skin dryness or cracking.
Precautionary Statements	P210-P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes	Xn:Harmful;
Risk Phrases	R21;R38;R41
Safety Phrases	S26-S36
RIDADR	2430
WGK Germany	2
RTECS	SM9625000
Packaging Group	III
Hazard Class	8
HS Code	29071300

Precursor 9
107-39-1 108-95-2 690-37-9 5413-23-0
107-40-4 6111-88-2 748815-18-1 139-02-6
71-43-2
DownStream 10
37693-05-3 110875-85-9 98-54-4 96-76-4
108-95-2 99-96-7 3001-56-7 27725-17-3
2315-67-5 83933-03-3

HS Code	2907139000
Summary	2907139000 3-octylphenol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

140-66-9	1173021-20-9
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1173020-24-0	68987-90-6
2315-61-9	3294-03-9
2315-62-0	13402-97-6