Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-amino-8-naphthol-2,4-disulfonic acid monosodium salt
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52789-62-5

52789-62-5 structure

52789-62-5 structure

Name: 1-amino-8-naphthol-2,4-disulfonic acid monosodium salt
Chemical Name: 1-Amino-8-naphthol-2,4-disulfonic Acid Monosodium Salt Hydrate
CAS Number: 52789-62-5
Molecular Formula: C₁₀H₈NNaO₇S₂
Molecular Weight: 341.29
Catalog: Organic raw materials Amino compound Oxy-containing amino compound
Create Date: 2019-01-01 20:17:51
Modify Date: 2024-01-12 18:18:07
CaMKP inhibitor sodium is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.

Name	1-Amino-8-naphthol-2,4-disulfonic Acid Monosodium Salt Hydrate
Synonyms	1-AMINO-8-NAPHTHOL-2,4-DISULFONIC ACID MONOSODIUM SALT MFCD00068275 Chicago Acid Hydrate SS Acid Hydrate Sodium Hydrogen 4-Amino-5-hydroxy-1,3-naphthalenedisulfonate Hydrate Monosodium 1-Amino-8-naphthol-2,4-disulfonate Hydrate EINECS 258-185-0 4-Amino-5-hydroxy-1,3-naphthalenedisulfonic Acid Monosodium Salt Hydrate 2S Acid Hydrate

Description	CaMKP inhibitor sodium is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	IC50: 14 nM (ROCK1)[1].
In Vitro	CaMKP inhibitor sodium at 1 μM reduces ROCK2 activity over 20-fold, under conditions in which the only other kinase tested that is significantly inhibited is MSK1 whose activity is reduced ~5-fold. CaMKP inhibitor sodium is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2). CaMKP inhibitor sodium slightly inhibits RSK and p70S6K with IC50 of 0.78 μM and 1.94 μM, respectively. CaMKP inhibitor sodium significantly inhibits rat aortic ring dilation with IC50 of 190 nM[2].
In Vivo	CaMKP inhibitor sodium has 61% oral bioavailability in male Sprague-Dawley rats. Oral administration of CaMKP inhibitor sodium at single doses of 3-30 mg/kg dramatically reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs) in a dose-dependent manner, with a maximum decrease of 50 mmHg after approximately 2 hours treatment at dose of 30 mg/kg[1].
References	[1]. Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9. [2]. Nichols RJ et al Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60.

Density	1.477 g/mL at 25 °C(lit.)
Boiling Point	270-272 °C(lit.)
Melting Point	12-16 °C(lit.)
Molecular Formula	C₁₀H₈NNaO₇S₂
Molecular Weight	341.29
Flash Point	>230 °F
Exact Mass	340.96400
PSA	174.58000
LogP	3.02120
Index of Refraction	n20/D 1.498(lit.)

Safety Phrases	S22-S24/25
HS Code	2922199090

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%