cycrimine

Modify Date: 2024-01-18 19:50:43

cycrimine structure	Common Name	cycrimine
	CAS Number	77-39-4	Molecular Weight	287.44000
	Density	1.057g/cm3	Boiling Point	433.5ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₉NO	Melting Point	N/A
	MSDS	N/A	Flash Point	205.7ºC

Use of cycrimine

Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].

Name	cycrimine
Synonym	More Synonyms

Description	Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1. [2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344. [3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-165. [4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8.

Description

Related Catalog

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

References

[1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1.

[2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344.

[3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-165.

[4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8.

Density	1.057g/cm3
Boiling Point	433.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₉NO
Molecular Weight	287.44000
Flash Point	205.7ºC
Exact Mass	287.22500
PSA	23.47000
LogP	3.87830
Index of Refraction	1.554

β-Piperidinopro...

CAS#:73-63-2

CYCLOPENTYLMAGN...

CAS#:33240-34-5

cycrimine

CAS#:77-39-4

Literature: Denton et al. Journal of the American Chemical Society, 1950 , vol. 72, p. 3792

Precursor 2
CAS#:73-63-2 β-Piperidinopro... CAS#:33240-34-5 CYCLOPENTYLMAGN...
DownStream 0

Cycriminum [INN-Latin]

Cicrimina

1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol

Cicrimina [INN-Spanish]

Cycriminum

1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol

1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol

Pagitane

1-Cyclopentyl-1-phenyl-1-piperidino-propan-1-ol

cycrimine

Use of cycrimine

Names

cycrimine Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms